RETRACTED: Enantioselective Organocatalytic Hantzsch Synthesis of Polyhydroquinolines (Retracted article. See vol. 23, pg. 3802, 2021)

被引：125

作者：

Evans, Christopher G.

Gestwicki, Jason E. ^{[1
]}

机构：

[1] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 14期

关键词：

ONE-POT SYNTHESIS; MICROWAVE-ASSISTED SYNTHESIS; EFFICIENT ONE-POT; MULTICOMPONENT REACTIONS; TRANSFER HYDROGENATION; 3-COMPONENT SYNTHESIS; BIGINELLI REACTION; MANNICH REACTIONS; DERIVATIVES; GENERATION;

D O I：

10.1021/ol901114f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The four-component Hantzsch reaction provides access to pharmaceutically important dihydropyridines. To expand the utility of this method, we have developed a route under organocatalytic conditions with good yields and excellent ee's. Through catalyst screening, we found that a BINOL-phosphoric acid allowed enantioselective synthesis of six-membered heterocycles with a variety of substitution patterns.

引用

页码：2957 / 2959

页数：3

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