Design, synthesis and bioactivity of novel herbicides targeted ALS (VII): Quantitative structure-activity relationships of herbicidal sulfonylureas

The quantitative relationship between the structures of 20 sulfonylureas and their herbicidal activities against rape was analyzed using physicochemical parameters and regression analysis. The results showed that the electronic properties of the molecules are the dominant factor to the activity and there is apparently an optimum electronic property (Sigma sigma or pK(a)) for the molecules to fit the receptor. Combined with the previous QSAR results for herbicidal triazolopyrimidine-2-sulfonamides, we can conclude that the structure-activity relationships of these two sets of compounds are identical, which suggested that these, two sets of compounds acted on the same target site.