Catalyst-free tandem aldol condensation/Michael addition of 1,3-cyclohexanediones with enolizable aldehydes

被引：13
|
作者：
Rohr, Kerstin [1 ]
Mahrwald, Rainer [1 ]
机构：
[1] Humboldt Univ, Inst Chem, D-12489 Berlin, Germany
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 14期
关键词：
Tandem aldol condensation/Michael addition; Enolizable aldehydes; 1,3-Cyclohexanediones; Catalyst-free; EFFICIENT SYNTHESIS; DERIVATIVES; 1,8-DIOXO-OCTAHYDROXANTHENES; ACID; XANTHENE; DIMEDONE;
D O I：
10.1016/j.bmcl.2009.03.040
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An efficient tandem aldol condensation/Michael addition process of unactivated aldehydes and 1,3-cyclohexanedione is described. This transformation proceeds without any catalyst at room temperature with high isolated yields. By a fine-tuning of reaction conditions an access to both the aldol condensation/ Michael addition products or to the dehydrated cyclized 9-substituted 1,8-dioxo-xanthenes is given. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3949 / 3951
页数：3
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