Phloroglucinols with Immunosuppressive Activities from the Fruits of Eucalyptus globulus

被引：18

作者：

Thi-Anh Pham ^{[1
,4
]}

Hu, Xiao-Long ^{[1
]}

Huang, Xiao-Jun ^{[2
]}

Ma, Ming-Xi ^{[3
]}

Feng, Jia-Hao ^{[1
]}

Li, Jun-Yan ^{[1
]}

Hou, Ji-Qin ^{[1
]}

Zhang, Pei-Lin ^{[1
]}

Van-Hung Nguyen ^{[4
]}

Manh-Tuyen Nguyen ^{[5
]}

Xiong, Fei ^{[3
]}

Fan, Chun-Lin ^{[2
]}

Zhang, Xiao-Qi ^{[2
]}

Ye, Wen-Cai ^{[2
]}

Wang, Hao ^{[1
]}

机构：

[1] China Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept TCM Pharmaceut, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China

[2] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[3] Southeast Univ, Jiangsu Lab Biomat & Devices, State Key Lab Bioelect, Nanjing 210009, Jiangsu, Peoples R China

[4] Haiphong Univ Med & Pharm, Sch Pharm, Dept Tradit Med, 72 A Nguyen Binh Khiem, Haiphong City, Vietnam

[5] Hanoi Univ Pharm, Dept Tradit Med, 13-15 Le Thanh Tong, Hanoi, Vietnam

来源：

JOURNAL OF NATURAL PRODUCTS | 2019年 / 82卷 / 04期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

INHIBITORS; MACROCARPALS; DERIVATIVES; LEAVES;

D O I：

10.1021/acs.jnatprod.8b00920

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new phloroglucinol derivatives, eucalyptins C-G (1-5), together with 13 known analogues (6-18) were isolated from the fruits of Eucalyptus globulus. The structures and absolute configurations of 1-5 were established by means of spectroscopic data analysis, computational calculation methods, and single-crystal X-ray diffraction. Compounds 1-18 were investigated for their immunosuppressive effects in vitro, and 1, 2, 6, and 7 displayed moderate inhibitory activities with IC50 values of 11.8, 10.2, 18.2, and 19.1 mu M, respectively. The stimulation index (SI) of 1 was 64.2 and was compared to that of cyclosporine A (SI = 149.57). Further study demonstrated that 1 exhibited an immunosuppressive effect through inducing apoptosis and inhibiting cytokine secretion.

引用

页码：859 / 869

页数：11

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