Platelet cloaking of circulating tumour cells in patients with metastatic prostate cancer: Results from ExPeCT, a randomised controlled trial

被引：15

作者：

Brady, Lauren ^{[1
]}

Hayes, Brian ^{[2
,3
]}

Sheill, Grainne ^{[4
]}

Baird, Anne-Marie ^{[1
]}

Guinan, Emer ^{[5
]}

Stanfill, Bryan ^{[6
]}

Vlajnic, Tatjana ^{[7
]}

Casey, Orla ^{[8
]}

Murphy, Verena ^{[8
]}

Greene, John ^{[1
]}

Allott, Emma H. ^{[1
,9
]}

Hussey, Juliette ^{[4
]}

Cahill, Fidelma ^{[10
]}

Van Hemelrijck, Mieke ^{[10
]}

Peat, Nicola ^{[11
]}

Mucci, Lorelei ^{[12
]}

Cunningham, Moya ^{[13
]}

Grogan, Liam ^{[14
]}

Lynch, Thomas ^{[15
]}

Manecksha, Rustom P. ^{[15
,16
]}

McCaffrey, John ^{[17
]}

O'Donnell, Dearbhaile ^{[18
]}

Sheils, Orla ^{[1
]}

O'Leary, John ^{[19
]}

Rudman, Sarah ^{[11
]}

McDermott, Ray ^{[20
]}

Finn, Stephen ^{[1
,8
,19
]}

机构：

[1] Trinity Coll Dublin, Trinity Translat Med Inst, Dept Histopathol & Morbid Anat, Dublin, Ireland

[2] Cork Univ Hosp, Dept Histopathol, Cork, Ireland

[3] Univ Coll Cork, Dept Pathol, Cork, Ireland

[4] Trinity Coll Dublin, Sch Med, Discipline Physiotherapy, Dublin, Ireland

[5] Trinity Coll Dublin, Sch Med, Dublin, Ireland

[6] Pacific Northwest Natl Lab, Richland, WA 99352 USA

[7] Univ Hosp Basel, Inst Pathol, Basel, Switzerland

[8] Canc Trials Ireland, Dublin, Ireland

[9] Queens Univ Belfast, Ctr Canc Res & Cell Biol, Belfast, Antrim, North Ireland

[10] Kings Coll London, Sch Canc & Pharmaceut Sci, Translat Oncol & Urol TOUR, London, England

[11] Guys & St Thomas NHS Fdn Trust, London, England

[12] Harvard TH Chan Sch Publ Hlth, Boston, MA USA

[13] St Lukes Hosp, Dept Radiat Oncol, Dublin, Ireland

[14] Beaumont Hosp, Dept Oncol, Dublin, Ireland

[15] St James Hosp, Dept Urol, Dublin, Ireland

[16] Trinity Coll Dublin, Dept Surg, Dublin, Ireland

[17] Mater Misericordiae Univ Hosp, Dept Oncol, Dublin, Ireland

[18] St James Hosp, HOPE Directorate, Dublin, Ireland

[19] St James Hosp, Dept Histopathol, Dublin, Ireland

[20] Tallaght Univ Hosp, Dept Oncol, Dublin, Ireland

来源：

PLOS ONE | 2020年 / 15卷 / 12期

关键词：

RESISTANCE EXERCISE; METABOLIC SYNDROME; BLOOD; DEVICE; COUNTS; RISK;

D O I：

10.1371/journal.pone.0243928

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background Circulating tumour cells (CTCs) represent a morphologically distinct subset of cancer cells, which aid the metastatic spread. The ExPeCT trial aimed to examine the effectiveness of a structured exercise programme in modulating levels of CTCs and platelet cloaking in patients with metastatic prostate cancer. Methods Participants (n = 61) were randomised into either standard care (control) or exercise arms. Whole blood was collected for all participants at baseline (T0), three months (T3) and six months (T6), and analysed for the presence of CTCs, CTC clusters and platelet cloaking. CTC data was correlated with clinico-pathological information. Results Changes in CTC number were observed within group over time, however no significant difference in CTC number was observed between groups over time. Platelet cloaking was identified in 29.5% of participants. A positive correlation between CTC number and white cell count (WCC) was observed (p = 0.0001), in addition to a positive relationship between CTC clusters and PSA levels (p = 0.0393). Conclusion The presence of platelet cloaking has been observed in this patient population for the first time, in addition to a significant correlation between CTC number and WCC. Trial registration ClincalTrials.gov identifier NCT02453139.

引用

页数：15

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