Platelet cloaking of circulating tumour cells in patients with metastatic prostate cancer: Results from ExPeCT, a randomised controlled trial

被引：15

作者：

Brady, Lauren ^{[1
]}

Hayes, Brian ^{[2
,3
]}

Sheill, Grainne ^{[4
]}

Baird, Anne-Marie ^{[1
]}

Guinan, Emer ^{[5
]}

Stanfill, Bryan ^{[6
]}

Vlajnic, Tatjana ^{[7
]}

Casey, Orla ^{[8
]}

Murphy, Verena ^{[8
]}

Greene, John ^{[1
]}

Allott, Emma H. ^{[1
,9
]}

Hussey, Juliette ^{[4
]}

Cahill, Fidelma ^{[10
]}

Van Hemelrijck, Mieke ^{[10
]}

Peat, Nicola ^{[11
]}

Mucci, Lorelei ^{[12
]}

Cunningham, Moya ^{[13
]}

Grogan, Liam ^{[14
]}

Lynch, Thomas ^{[15
]}

Manecksha, Rustom P. ^{[15
,16
]}

McCaffrey, John ^{[17
]}

O'Donnell, Dearbhaile ^{[18
]}

Sheils, Orla ^{[1
]}

O'Leary, John ^{[19
]}

Rudman, Sarah ^{[11
]}

McDermott, Ray ^{[20
]}

Finn, Stephen ^{[1
,8
,19
]}

机构：

[1] Trinity Coll Dublin, Trinity Translat Med Inst, Dept Histopathol & Morbid Anat, Dublin, Ireland

[2] Cork Univ Hosp, Dept Histopathol, Cork, Ireland

[3] Univ Coll Cork, Dept Pathol, Cork, Ireland

[4] Trinity Coll Dublin, Sch Med, Discipline Physiotherapy, Dublin, Ireland

[5] Trinity Coll Dublin, Sch Med, Dublin, Ireland

[6] Pacific Northwest Natl Lab, Richland, WA 99352 USA

[7] Univ Hosp Basel, Inst Pathol, Basel, Switzerland

[8] Canc Trials Ireland, Dublin, Ireland

[9] Queens Univ Belfast, Ctr Canc Res & Cell Biol, Belfast, Antrim, North Ireland

[10] Kings Coll London, Sch Canc & Pharmaceut Sci, Translat Oncol & Urol TOUR, London, England

[11] Guys & St Thomas NHS Fdn Trust, London, England

[12] Harvard TH Chan Sch Publ Hlth, Boston, MA USA

[13] St Lukes Hosp, Dept Radiat Oncol, Dublin, Ireland

[14] Beaumont Hosp, Dept Oncol, Dublin, Ireland

[15] St James Hosp, Dept Urol, Dublin, Ireland

[16] Trinity Coll Dublin, Dept Surg, Dublin, Ireland

[17] Mater Misericordiae Univ Hosp, Dept Oncol, Dublin, Ireland

[18] St James Hosp, HOPE Directorate, Dublin, Ireland

[19] St James Hosp, Dept Histopathol, Dublin, Ireland

[20] Tallaght Univ Hosp, Dept Oncol, Dublin, Ireland

来源：

PLOS ONE | 2020年 / 15卷 / 12期

关键词：

RESISTANCE EXERCISE; METABOLIC SYNDROME; BLOOD; DEVICE; COUNTS; RISK;

D O I：

10.1371/journal.pone.0243928

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background Circulating tumour cells (CTCs) represent a morphologically distinct subset of cancer cells, which aid the metastatic spread. The ExPeCT trial aimed to examine the effectiveness of a structured exercise programme in modulating levels of CTCs and platelet cloaking in patients with metastatic prostate cancer. Methods Participants (n = 61) were randomised into either standard care (control) or exercise arms. Whole blood was collected for all participants at baseline (T0), three months (T3) and six months (T6), and analysed for the presence of CTCs, CTC clusters and platelet cloaking. CTC data was correlated with clinico-pathological information. Results Changes in CTC number were observed within group over time, however no significant difference in CTC number was observed between groups over time. Platelet cloaking was identified in 29.5% of participants. A positive correlation between CTC number and white cell count (WCC) was observed (p = 0.0001), in addition to a positive relationship between CTC clusters and PSA levels (p = 0.0393). Conclusion The presence of platelet cloaking has been observed in this patient population for the first time, in addition to a significant correlation between CTC number and WCC. Trial registration ClincalTrials.gov identifier NCT02453139.

引用

页数：15

共 50 条

[1] The ExPeCT (Examining Exercise, Prostate Cancer and Circulating Tumour Cells) trial: study protocol for a randomised controlled trial
Gráinne Sheill
Lauren Brady
Emer Guinan
Brian Hayes
Orla Casey
John Greene
Tatjana Vlajnic
Fidelma Cahill
Mieke Van Hemelrijck
Nicola Peat
Sarah Rudman
Juliette Hussey
Moya Cunningham
Liam Grogan
Thomas Lynch
Rustom P. Manecksha
John McCaffrey
Lorelei Mucci
Orla Sheils
John O’Leary
Dearbhaile M. O’Donnell
Ray McDermott
Stephen Finn
Trials, 18
[2] The ExPeCT (Examining Exercise, Prostate Cancer and Circulating Tumour Cells) trial: study protocol for a randomised controlled trial
Sheill, Grainne
Brady, Lauren
Guinan, Emer
Hayes, Brian
Casey, Orla
Greene, John
Vlajnic, Tatjana
Cahill, Fidelma
Van Hemelrijck, Mieke
Peat, Nicola
Rudman, Sarah
Hussey, Juliette
Cunningham, Moya
Grogan, Liam
Lynch, Thomas
Manecksha, Rustom P.
McCaffrey, John
Mucci, Lorelei
Sheils, Orla
O'Leary, John
O'Donnell, Dearbhaile M.
McDermott, Ray
Finn, Stephen
TRIALS, 2017, 18
[3] Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial
Parker, Christopher C.
James, Nicholas D.
Brawley, Christopher D.
Clarke, Noel W.
Hoyle, Alex P.
Ali, Adnan
Ritchie, Alastair W. S.
Attard, Gerhardt
Chowdhury, Simon
Cross, William
Dearnaley, David P.
Gillessen, Silke
Gilson, Clare
Jones, Robert J.
Langley, Ruth E.
Malik, Zafar I.
Mason, Malcolm D.
Matheson, David
Millman, Robin
Russell, J. Martin
Thalmann, George N.
Amos, Claire L.
Alonzi, Roberto
Bahl, Amit
Birtle, Alison
Din, Omar
Douis, Hassan
Eswar, Chinnamani
Gale, Joanna
Gannon, Melissa R.
Jonnada, Sai
Khaksar, Sara
Lester, Jason F.
O'Sullivan, Joe M.
Parikh, Omi A.
Pedley, Ian D.
Pudney, Delia M.
Sheehan, Denise J.
Srihari, Narayanan Nair
Tran, Anna T. H.
Parmar, Mahesh K. B.
Sydes, Matthew R.
LANCET, 2018, 392 (10162): : 2353 - 2366
[4] Phenotypic diversity of circulating tumour cells in patients with metastatic castration-resistant prostate cancer
McDaniel, Andrew S.
Ferraldeschi, Roberta
Krupa, Rachel
Landers, Mark
Graf, Ryon
Louw, Jessica
Jendrisak, Adam
Bales, Natalee
Marrinucci, Dena
Zafeiriou, Zafeiris
Flohr, Penelope
Sideris, Spyridon
Crespo, Mateus
Figueiredo, Ines
Mateo, Joaquin
de Bono, Johann S.
Dittamore, Ryan
Tomlins, Scott A.
Attard, Gerhardt
BJU INTERNATIONAL, 2017, 120 (5B) : E30 - E44
[5] ExPeCT: a randomised trial examining the impact of exercise on quality of life in men with metastatic prostate cancer
Sheill, Grainne
Brady, Lauren
Hayes, Brian
Baird, Anne-Marie
Guinan, Emer
Vishwakarma, Rishabh
Brophy, Caroline
Vlajnic, Tatjana
Casey, Orla
Murphy, Verena
Greene, John
Allott, Emma
Hussey, Juliette
Cahill, Fidelma
Van Hemelrijck, Mieke
Peat, Nicola
Mucci, Lorelei
Cunningham, Moya
Grogan, Liam
Lynch, Thomas
Manecksha, Rustom P.
McCaffrey, John
O'Donnell, Dearbhaile
Sheils, Orla
O'Leary, John
Rudman, Sarah
McDermott, Ray
Finn, Stephen
SUPPORTIVE CARE IN CANCER, 2023, 31 (05)
[6] ExPeCT: a randomised trial examining the impact of exercise on quality of life in men with metastatic prostate cancer
Gráinne Sheill
Lauren Brady
Brian Hayes
Anne-Marie Baird
Emer Guinan
Rishabh Vishwakarma
Caroline Brophy
Tatjana Vlajnic
Orla Casey
Verena Murphy
John Greene
Emma Allott
Juliette Hussey
Fidelma Cahill
Mieke Van Hemelrijck
Nicola Peat
Lorelei Mucci
Moya Cunningham
Liam Grogan
Thomas Lynch
Rustom P. Manecksha
John McCaffrey
Dearbhaile O’Donnell
Orla Sheils
John O’Leary
Sarah Rudman
Ray McDermott
Stephen Finn
Supportive Care in Cancer, 2023, 31
[7] Molecular markers in circulating tumour cells from metastatic colorectal cancer patients
Gazzaniga, Paola
Gradilone, Angela
Petracca, Arianna
Nicolazzo, Chiara
Raimondi, Cristina
Iacovelli, Roberto
Naso, Giuseppe
Cortesi, Enrico
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2010, 14 (08) : 2073 - 2077
[8] Radiotherapy to the prostate for men with metastatic prostate cancer in the UK and Switzerland: Long-term results from the STAMPEDE randomised controlled trial
Parker, Chris
James, Nicholas L.
Brawley, Christopher
Clarke, Noel
Ali, Adnan
Amos, Claire
Attard, Gerhardt P.
Chowdhury, Simon
Cook, Adrian C.
Cross, William
Dearnaley, David
Douis, Hassan
Gilbert, Duncan J.
Gilson, Clare E.
Gillessen, Silke I.
Hoyle, Alex D.
Jones, Rob
Langley, Ruth
Malik, Zafar
Mason, Malcolm
Matheson, David
Millman, Robin
Rauchenberger, Mary
Rush, Hannah
Russell, J. Martin
Sweeney, Hannah
Bahl, Amit
Birtle, Alison
Capaldi, Lisa
Din, Omar
Ford, Daniel
Gale, Joanna
Henry, Ann M.
Hoskin, Peter A.
Kagzi, Mohammed
Lydon, Anna
O'Sullivan, Joe
Paisey, Sangeeta
Parikh, Omi
Pudney, Delia
Ramani, Vijay
Robson, Peter R.
Srihari, Narayanan Nair
Tanguay, Jacob
Parmar, Mahesh K. B.
Sydes, Matthew
STAMPEDETrialCollaborativeGroup
PLOS MEDICINE, 2022, 19 (06)
[9] The effect of a structured exercise intervention on CTCs and platelet cloaking in patients with metastatic prostate cancer.
Brady, Lauren
Hayes, Brian
Sheill, Grainne
Baird, Anne-Marie
Guinan, Emer M.
Stanfill, Bryan
Vlajnic, Tatjana
Casey, Orla
Greene, John Patrick
Allott, Emma
Hussey, Juliette M.
Cahill, Fidelma
Van Hemelrijck, Mieke
Peat, Nicola
Rudman, Sarah Maria
Mucci, Lorelei
Sheils, Orla
John, O'Leary
McDermott, Ray
Finn, Stephen P.
JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (07)
[10] Re: Radiotherapy to the Primary Tumour for Newly Diagnosed, Metastatic Prostate Cancer (STAMPEDE): A Randomised Controlled Phase 3 Trial
Tilki, Derya
Evans, Christopher P.
EUROPEAN UROLOGY, 2019, 75 (03) : 535 - 536

← 1 2 3 4 5 →