An Improved Protocol for the Synthesis of α-Trifluoromethylthio-Substituted Ketones by Copper-Mediated Trifluoromethylthiolation of α-Bromo Ketones

被引：48

作者：

Huang, Yangjie ^{[1
]}

He, Xing ^{[1
]}

Li, Haohong ^{[1
]}

Weng, Zhiqiang ^{[1
]}

机构：

[1] Fuzhou Univ, Dept Chem, Fuzhou 350108, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 33期

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

Synthetic methods; Trifluoromethylthiolation; Copper; Ketones; Fluorine; SILYL ENOL ETHERS; MILD ELECTROPHILIC TRIFLUOROMETHYLATION; METAL-CATALYZED TRIFLUOROMETHYLATION; HYPERVALENT IODINE REAGENT; ARYL BORONIC ACIDS; RADICAL TRIFLUOROMETHYLATION; NUCLEOPHILIC TRIFLUOROMETHYLTHIOLATION; OXIDATIVE TRIFLUOROMETHYLTHIOLATION; ASYMMETRIC FLUORINATION; BETA-KETOESTERS;

D O I：

10.1002/ejoc.201403221

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and practical approach to -trifluoromethylthio-substituted ketones was developed. The trifluoromethylthiolation of (bpy)Cu(SCF3) (bpy = 2,2-bipyridyl) with various -bromo ketones afforded the desired -trifluoromethylthio-substituted ketones in good yields. The reaction tolerates more functionally than previously reported methods and demonstrates efficient scalability and practicality.

引用

页码：7324 / 7328

页数：5

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