Antifungal Activities of Natural and Synthetic Iron Chelators Alone and in Combination with Azole and Polyene Antibiotics against Aspergillus fumigatus

被引：59

作者：

Zarember, Kol A. ^{[1
]}

Cruz, Anna R. ^{[1
]}

Huang, Chiung-Yu ^{[2
]}

Gallin, John I. ^{[1
]}

机构：

[1] Host Def Lab, Bethesda, MD 20892 USA

[2] NIAID, Biostat Res Branch, NIH, Bethesda, MD 20892 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 06期

关键词：

STEM-CELL TRANSPLANTATION; FUNGAL-INFECTIONS; INVASIVE ASPERGILLOSIS; PRIMARY IMMUNODEFICIENCIES; THERAPY; MUCORMYCOSIS; ITRACONAZOLE; POSACONAZOLE; FLUCONAZOLE; NEUTROPENIA;

D O I：

10.1128/AAC.01547-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antifungal effects of iron chelators (lactoferrin, deferoxamine, deferiprone, and ciclopirox) were tested alone and in combination with antifungal drugs against Aspergillus fumigatus B5233 conidia. Lactoferrin, ciclopirox, and deferiprone inhibited whereas deferoxamine enhanced fungal growth. Antifungal synergy against conidia was observed for combinations of ketoconazole with ciclopirox or deferiprone, lactoferrin with amphotericin B, and fluconazole with deferiprone. Iron chelation alone or combined with antifungal drugs may be useful for prevention and treatment of mycosis.

引用

页码：2654 / 2656

页数：3

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