Human resources are the determining factors for economical growth and development. Under the knowledge-based economy condition, human resource management is important in an enterprise's status. Enterprise's competitive advantage and the sustainable development ability reflect the competition of "the talented persons" with traits such as decision power, management ability, technical development ability and innovation ability. In face of the knowledge economy and the economical globalization, how to use and manage a team of high quality talented people to accumulate energy for the enterprise's technical innovation, product innovation and sustainable coordinated development determines the enterprise's success or failure. The enterprise's human resource management should comply with the environmental variation, change the management conception, the management methods, the appraisal system and the distribution pattern and develop the human resources in integrity so as to adapt to the knowledge economy's movement rhythm, to realize the coordination of human resources management strategy and overall strategy of enterprise, to achieve the enterprise's strategic target and promote the enterprise's speedy development. This article emphatically elaborates on the reshipment of human resources management in knowledge-based economy time, and discusses such aspects as to set up the humanist management idea, to establish a specialized human resources management team, to establish a well organized enterprise structure, to establish a perfectly scientific talent development strategy. Meanwhile, it also can find an excellent enterprise culture and establish a fair performance appraisal system. Therefore, it further implements a drive-guidance salary and the welfare system as well as perfecting the management method.