Narrowband UVB phototherapy for early-stage mycosis fungoides

被引：141
|
作者：
Gathers, RC [1 ]
Scherschun, L [1 ]
Malick, F [1 ]
Fivenson, DP [1 ]
Lim, HW [1 ]
机构：
[1] Henry Ford Hlth Syst, Dept Dermatol, Detroit, MI USA
来源：
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2002年 / 47卷 / 02期
关键词：
D O I：
10.1067/mjd.2002.120911
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Background: Narrowband UVB (NB-UVB) phototherapy has been shown to be effective for the treatment of various dermatoses. Objective. We evaluated the effect of NB-UVB in the treatment of early stage mycosis fungoides (MF) Methods. The response of 24 patients (12 stage IA, 12 stage 1B) with patch stage MF to thrice weekly NB-UVB was assessed. Twelve patients had skin phototypes I-III, and 12 had types IV-VI. Seven patients had hypopigmented MF. Mean follow-up period was 29.0 weeks. Results: Thirteen patients (54.2%) had a complete response (CR), 7 (29.2%) had partial response (PR), and 4 (16.7%) had no response. Specimens from a repeat biopsy in 10 patients with CR showed histologic clearing in 9 of them. Upon discontinuation of treatment, 4 patients with CR relapsed, with a mean time to relapse of 12.5 weeks. Conclusion: NB-UVB is a viable, comparably safe, and easily administered alternative in the management of early stage MF.
引用
收藏
页码：191 / 197
页数：7
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