Solubility profiles of some isoxazolyl-naphthoquinone derivatives

被引：6

作者：

Granero, G ^{[1
]}

de Bertorello, MM ^{[1
]}

Briñón, MC ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Farm, RA-5000 Cordoba, Argentina

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1999年 / 190卷 / 01期

关键词：

1,2-naphthoquinones; solubility study; dissolution profile; acid dissociation constant; intrinsic aqueous solubility;

D O I：

10.1016/S0378-5173(99)00245-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Water, ethanol and n-hexane solubility and pH-solubility behavior of a homologous series of isoxazolyl-naphthoquinone derivatives, which exhibit important biological activity, were studied. Their pK(a) values were determined spectrophotometrically as well as from their pH-solubility profiles. Also, the molar aqueous solubility of these compounds was estimated with the equations developed by Yalkowsky and Valvani using the data of their melting points and octanol/water partition coefficients. (C) 1999 Elsevier Science: B.V. All rights reserved.

引用

页码：41 / 47

页数：7

共 50 条

[21] FUNGAL METABOLITES .2. SYNTHESIS OF SOME 1,4-NAPHTHOQUINONE DERIVATIVES
COOMBE, RG
[J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1972, 25 (04) : 881 - &
[22] Antitrypanosomal activities and cytotoxicity of some novel imidosubstituted 1,4-naphthoquinone derivatives
Mozna H. Khraiwesh
Clarence M. Lee
Yakini Brandy
Emmanuel S. Akinboye
Solomon Berhe
Genelle Gittens
Muneer M. Abbas
Franklin R. Ampy
Mohammad Ashraf
Oladapo Bakare
[J]. Archives of Pharmacal Research, 2012, 35 : 27 - 33
[23] Electron attachment to some naphthoquinone derivatives: long-lived molecular anion formation
Asfandiarov, N. L.
Pshenichnyuk, S. A.
Vorob'ev, A. S.
Nafikova, E. P.
Elkin, Y. N.
Pelageev, D. N.
Koltsova, E. A.
Modelli, A.
[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2014, 28 (14) : 1580 - 1590
[24] INVESTIGATIONS IN 1,4-NAPHTHOQUINONE FIELD .I. SOME 2,3-DERIVATIVES OF 1,4-NAPHTHOQUINONE
BOLDYREV, BG
KOLESNIK.VT
[J]. JOURNAL OF GENERAL CHEMISTRY USSR, 1966, 36 (04): : 649 - &
[25] Solubility-pH profiles of some acidic, basic and amphoteric drugs
Shoghi, Elham
Fuguet, Elisabet
Bosch, Elisabeth
Rafols, Clara
[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2013, 48 (1-2) : 291 - 300
[26] DIELECTRIC SOLUBILITY PROFILES OF ACETANILIDE AND SEVERAL DERIVATIVES IN DIOXANE-WATER MIXTURES
PARUTA, AN
SCIARRONE, BJ
LORDI, NG
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (09) : 1325 - +
[27] COMPARATIVE STUDY ON ACTION PROFILES OF SOME BENZODIAZEPINE DERIVATIVES
REIMER, F
[J]. ARZNEIMITTEL-FORSCHUNG, 1968, 18 (12): : 1568 - &
[28] Intramolecular Photoredox Reaction of Naphthoquinone Derivatives
Ando, Yoshio
Matsumoto, Takashi
Suzuki, Keisuke
[J]. SYNLETT, 2017, 28 (09) : 1040 - 1045
[29] Naphthoquinone Derivatives from Diospyros maritima
Higa, Matsutake
Takashima, Yuji
Yokaryo, Hiroto
Harie, Yuta
Suzuka, Toshimasa
Ogihara, Kazuhito
[J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2017, 65 (08) : 739 - 745
[30] ANTICOAGULANT EFFECTS OF 2 NAPHTHOQUINONE DERIVATIVES
MIGNON, P
[J]. ANNALES PHARMACEUTIQUES FRANCAISES, 1968, 26 (05): : 417 - &

← 1 2 3 4 5 →