Solubility profiles of some isoxazolyl-naphthoquinone derivatives

被引：6

作者：

Granero, G ^{[1
]}

de Bertorello, MM ^{[1
]}

Briñón, MC ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Farm, RA-5000 Cordoba, Argentina

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1999年 / 190卷 / 01期

关键词：

1,2-naphthoquinones; solubility study; dissolution profile; acid dissociation constant; intrinsic aqueous solubility;

D O I：

10.1016/S0378-5173(99)00245-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Water, ethanol and n-hexane solubility and pH-solubility behavior of a homologous series of isoxazolyl-naphthoquinone derivatives, which exhibit important biological activity, were studied. Their pK(a) values were determined spectrophotometrically as well as from their pH-solubility profiles. Also, the molar aqueous solubility of these compounds was estimated with the equations developed by Yalkowsky and Valvani using the data of their melting points and octanol/water partition coefficients. (C) 1999 Elsevier Science: B.V. All rights reserved.

引用

页码：41 / 47

页数：7

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