Treatment of Oral Inflammatory Diseases with a New Mucoadhesive Prednisolone Tablet Versus Triamcinolone Acetonide Paste

Background: The existing clinical trials have shown that topical corticosteroids are often effective in the management of oral inflammatory diseases. The purpose of this study was to compare the effectiveness and safety of a new mucoadhesive prednisolone tablet with that of triamcinolone acetonid paste in the management of oral lesions such as RAS-EM-pemphigus vulgaris-recurrent intraoral herpes-OLP and chemical burn. Methods: In this randomized comparative study, 60 consecutive patients with oral lesions were recruited. The patients were divided into 2 groups, one receiving topical triamcinolone acetonid 0.1% paste and the other prednisolone 5 mg mucoadhesive tablet for 2 weeks. Results: The profiles of mean lesion sizes and mean pain measures did not show any difference between the prednisolone and triamcinolone groups. Conclusion: It was found that prednisolone 5mg table is useful as triamcinolone paste in the treatment of oral inflammatory lesions with minimal side effects.