Intravascular large B-cell lymphoma associated with a near-tetraploid karyotype, rearrangement of BCL6, and a t(11;14)(q13;q32)

被引：11
|
作者：
Rashid, Rumana
Johnson, Roderick J.
Morris, Stephen
Dickinson, Helen
Czyz, Jarek
O'Connor, Sheila J. M.
Owen, Roger G.
机构：
[1] Leeds Teaching Hosp NHS Trust, HMDS Lab, Leeds LS1 3EX, W Yorkshire, England
[2] Gen Infirm Leeds, Leeds Teaching Hosp NHS Trust, Dept Hematol, Leeds, W Yorkshire, England
[3] Leeds Teaching Hosp NHS Trust, Reg Cytogenet Unit, Leeds, W Yorkshire, England
[4] Huddersfield Royal Infirm, Dept Hematol, Huddersfield HD3 3EA, W Yorkshire, England
来源：
CANCER GENETICS AND CYTOGENETICS | 2006年 / 171卷 / 02期
关键词：
D O I：
10.1016/j.cancergencyto.2006.07.018
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chromosome analysis of a patient with intravascular large B-cell lymphoma (IVL) revealed a complex, near-tetraploid karyotype with 83 chromosomes. Abnormalities included a t(11;14)(q13;q32), which was confirmed with both interphase fluorescence in situ hybridization (FISH) using an IGH/ cyclin D1 dual-color, dual-fusion probe set and cyclin D1 immunohistochemical analysis. Abnormality of 3q was also evident. Interphase FISH analysis with a dual-color, break-apart probe set confirmed rearrangement of BCL6. To our knowledge, this is the first report of these abnormalities in IVL. (c) 2006 Elsevier Inc. All rights reserved.
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收藏
页码：101 / 104
页数：4
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