Bisphosphonates in Bone Diseases Treatment

Bisphosphonates are the most frequently used drugs in the treatment of various bone and cancer diseases. They are complex chemical compounds, having a structure similar to that of pyrophosphates, but with certain differences: i.e., bisphosphonates have P-C-P in their composition; instead of an oxygen atom, a carbon atom is present. The R1 and R2 chains bind to the carbon atom and thus, the antiresorptive capacity of bisphosphonates on the one hand, and their bone-binding capacity on the other hand are stimulated. Through their action, they favor the treatment of diseases for which they have been prescribed, but they can also favor a number of undesired side effects.