Viral pathogenesis of SARS-CoV-2 infection and male reproductive health

被引:19
|
作者
Roychoudhury, Shubhadeep [1 ]
Das, Anandan [1 ]
Jha, Niraj Kumar [2 ]
Kesari, Kavindra Kumar [3 ]
Roychoudhury, Shatabhisha [4 ,5 ]
Jha, Saurabh Kumar [2 ]
Kosgi, Raghavender [6 ]
Choudhury, Arun Paul [7 ]
Lukac, Norbert [8 ]
Madhu, Nithar Ranjan [9 ]
Kumar, Dhruv [10 ]
Slama, Petr [11 ]
机构
[1] Assam Univ, Dept Life Sci & Bioinformat, Silchar, India
[2] Sharda Univ, Sch Engn & Technol SET, Dept Biotechnol, Greater Noida, UP, India
[3] Aalto Univ, Sch Sci, Dept Appl Phys, Espoo, Finland
[4] RG Kar Med Coll & Hosp, Dept Microbiol, Kolkata, India
[5] Assam Univ, Hlth Ctr, Silchar, India
[6] AIG Hosp, Dept Urol & Androl, Hyderabad, India
[7] Silchar Med Coll & Hosp, Dept Obstet & Gynecol, Silchar, India
[8] Slovak Univ Agr, Fac Biotechnol & Food Sci, Nitra, Slovakia
[9] Acharya Prafulla Chandra Coll, Dept Zool, North 24 Parganas, New Barrackpore, W Bengal, India
[10] Amity Univ, Amity Inst Mol Med & Stem Cell Res, Noida, India
[11] Mendel Univ Brno, Fac AgriSci, Dept Anim Morphol Physiol & Genet, Brno, Czech Republic
关键词
SARS-CoV-2; infection; COVID-19; ACE2; male reproduction; testicular damage; fertility; OXIDATIVE STRESS; MALE-INFERTILITY; MALE-FERTILITY; COVID-19; CORONAVIRUS; CELLS; ACE2; SEX; IMPACT; TESTES;
D O I
10.1098/rsob.200347
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Coronavirus disease 2019 (COVID-19) has emerged as a new public health crisis, threatening almost all aspects of human life. Originating in bats, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted to humans through unknown intermediate hosts, where it is primarily known to cause pneumonia-like complications in the respiratory system. Organ-to-organ transmission has not been ruled out, thereby raising the possibility of the impact of SARS-CoV-2 infection on multiple organ systems. The male reproductive system has been hypothesized to be a potential target of SARS-CoV-2 infection, which is supported by some preliminary evidence. This may pose a global threat to male fertility potential, as men are more prone to SARS-CoV-2 infection than women, especially those of reproductive age. Preliminary reports have also indicated the possibility of sexual transmission of SARS-CoV-2. It may cause severe complications in infected couples. This review focuses on the pathophysiology of potential SARS-CoV-2 infection in the reproductive organs of males along with their invasion mechanisms. The risks of COVID-19 on male fertility as well as the differences in vulnerability to SARS-CoV-2 infection compared with females have also been highlighted.
引用
收藏
页数:11
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