α-synuclein and the pathogenesis of Parkinson's disease

被引：25

作者：

Martin, FL ^{[1
]}

Williamson, SJM ^{[1
]}

Paleologou, KE ^{[1
]}

Allsop, D ^{[1
]}

El-Agnaf, OMA ^{[1
]}

机构：

[1] Univ Lancaster, IENS, Dept Biol Sci, Lancaster LA1 4YQ, England

来源：

PROTEIN AND PEPTIDE LETTERS | 2004年 / 11卷 / 03期

关键词：

Parkinson's disease; DNA single-strand breaks; Fe(II); alpha-synuclein; Comet assay; comet tail length; reactive oxygen species; environmental causation;

D O I：

10.2174/0929866043407138

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson's disease (PD) patients. Intracellular aggregation of alpha-synuclein (alpha-syn) appears to play a key role in the generation of LBs and LNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.

引用

页码：229 / 237

页数：9

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