The role of nutrition in canine idiopathic epilepsy management: Fact or fiction?

被引：3

作者：

Verdoodt, Fien ^{[1
,2
]}

Watanangura, Antja ^{[3
,4
,5
]}

Bhatti, Sofie F. M. ^{[2
]}

Schmidt, Teresa ^{[3
,4
]}

Suchodolski, Jan S. ^{[6
]}

Van Ham, Luc ^{[2
]}

Meller, Sebastian ^{[3
]}

Volk, Holger A. ^{[3
,4
]}

Hesta, Myriam ^{[1
]}

机构：

[1] Univ Ghent, Fac Vet Med, Equine & Compan Anim Nutr, Dept Morphol Imaging Orthoped Rehabil & Nutr, Merelbeke, Belgium

[2] Univ Ghent, Fac Vet Med, Small Anim Dept, Merelbeke, Belgium

[3] Univ Vet Med Hannover, Dept Small Anim Med & Surg, Hannover, Germany

[4] Ctr Syst Neurosci ZSN, Hannover, Germany

[5] Kasetsart Univ, Vet Res & Acad Serv, Fac Vet Med, Kamphaeng Saen, Nakhon Pathom, Thailand

[6] Texas A&M Univ, Coll Vet Med & Biomed Sci, Gastrointestinal Lab, Dept Small Anim Clin Sci, College Stn, TX USA

来源：

VETERINARY JOURNAL | 2022年 / 290卷

关键词：

Dog; Epilepsy; Medium chain triglycerides; Microbiota-gut-brain axis; Nutraceuticals; POLYUNSATURATED FATTY-ACIDS; SERUM BROMIDE CONCENTRATIONS; DIETARY CHLORIDE CONTENT; KETOGENIC DIET; DECANOIC ACID; BRAIN METABOLISM; GUT MICROBIOME; DOGS; MECHANISMS; OMEGA-3-FATTY-ACIDS;

D O I：

10.1016/j.tvjl.2022.105917

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

In the last decade, nutrition has gained interest in the management of canine idiopathic epilepsy (IE) based on growing scientific evidence. Diets can serve their functions through many pathways. One potential pathway includes the microbiota-gut-brain axis, which highlights the relationship between the brain and the intestines. Changing the brain's energy source and a number of dietary sourced anti-inflammatory and neuroprotective factors appears to be the basis for improved outcomes in IE. Selecting a diet with anti-seizure effects and avoiding risks of proconvulsant mediators as well as interference with anti-seizure drugs should all be considered in canine IE. This literature review provides information about preclinical and clinical evidence, including a systematic evaluation of the level of evidence, suggested mechanism of action and interaction with anti-seizure drugs as well as pros and cons of each potential dietary adaptation in canine IE.

引用

页数：11

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