Context dependent effects of ventral tegmental area inactivation on spatial working memory

被引：13
|
作者：
Martig, Adria K. [1 ]
Jones, Graham L. [1 ]
Smith, Kelsey E. [1 ]
Mizumori, Sheri J. Y. [1 ,2 ]
机构：
[1] Univ Washington, Dept Psychol, Seattle, WA 98195 USA
[2] Univ Washington, Neurobiol & Behav Program, Seattle, WA 98195 USA
来源：
BEHAVIOURAL BRAIN RESEARCH | 2009年 / 203卷 / 02期
关键词：
Hippocampus; Ventral tegmental area; Working memory; Context; NUCLEUS-ACCUMBENS; PREFRONTAL CORTEX; DOPAMINE NEURONS; MAZE TASKS; HIPPOCAMPAL; MODULATION; RECEPTORS; INFORMATION; INVOLVEMENT; RESPONSES;
D O I：
10.1016/j.bbr.2009.05.008
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Rats were tested on a hippocampus dependent win-shift working memory task in familiar or novel environments after receiving bilateral ventral tegmental area infusions of baclofen. Baclofen infusion disrupted working memory performance in both familiar and novel environments. In addition, baclofen infusion selectively disrupted short-term working memory in the novel environment. This experiment confirms selective ventral tegmental area support of accurate performance during a context dependent spatial navigation task. Published by Elsevier B.V.
引用
收藏
页码：316 / 320
页数：5
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