Impact of Molecular Adsorbent Recirculating System Therapy on Tacrolimus Elimination: A Case Report

被引：5
|
作者：
Personett, H. A. [1 ]
Larson, S. L. [1 ]
Frazee, E. N. [1 ]
Nyberg, S. L. [2 ]
Leung, N. [3 ]
EI-Zoghby, Z. M. [3 ]
机构：
[1] Mayo Clin Hosp, Dept Pharm Serv, Rochester, MN USA
[2] Mayo Clin Hosp, Dept Transplantat Surg, Rochester, MN USA
[3] Mayo Clin Hosp, Dept Hypertens & Nephrol, Rochester, MN USA
来源：
TRANSPLANTATION PROCEEDINGS | 2014年 / 46卷 / 07期
关键词：
INTRACTABLE PRURITUS; ALBUMIN DIALYSIS; CHOLESTASIS; MARS;
D O I：
10.1016/j.transproceed.2014.02.013
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background. We report a unique case which quantifies the effect of molecular adsorbent recirculating system (MARS [Gambro, Sweden]) therapy on blood concentrations of tacrolimus in a patient treated for refractory pruritus associated with recurrent hepatitis C of the liver allograft. Tacrolimus is a low-molecular-weight, highly protein-bound drug with the potential to be removed during MARS therapy. Case Report. Results of therapeutic drug monitoring revealed extracorporeal tacrolimus elimination accounted for only 0.3% of total drug removal during the session. Conclusions. Although no explanation can be offered as to why MARS contributed so little to overall tacrolimus elimination, the data clearly show minimal impact of MARS on tacrolimus blood level.
引用
收藏
页码：2440 / 2442
页数：3
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