Highly efficient one-pot four-component Kabachnik-Fields synthesis of novel α-amino phosphonates under solvent-free and catalyst-free conditions

被引：10

作者：

Rashid, Zahra ^{[1
]}

Naeimi, Hossein ^{[2
]}

Ghahremanzadeh, Ramin ^{[1
]}

机构：

[1] ACECR, Avicenna Res Inst, Nanobiotechnol Res Ctr, Tehran, Iran

[2] Univ Kashan, Fac Chem, Dept Organ Chem, Kashan 87317, Iran

来源：

RSC ADVANCES | 2015年 / 5卷 / 120期

关键词：

3-COMPONENT SYNTHESIS; ANTITUMOR-ACTIVITY; AMINOPHOSPHONATES; ACID; AMBIENT;

D O I：

10.1039/c5ra18311a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the present study, a simple and highly efficient protocol for the preparation of novel alpha-amino phosphonates is achieved based on the one-pot reaction of ninhydrin, 1,2-phenylenediamines, aniline derivatives, and dialkyl or diaryl phosphites, without using any catalyst under solvent-free conditions. The main advantages of the reaction are short reaction time, high yields, simple workup, and no need for further purification.

引用

页码：99148 / 99152

页数：5

共 50 条

[31] Al(H2PO4)3 as an Efficient and Reusable Catalyst for One-pot Three-component Synthesis of α-Amino Phosphonates under Solvent-free Conditions
Maghsoodlou, Malek Taher
Habibi-Khorassani, Sayyed Mostafa
Heydari, Reza
Hazeri, Nourollah
Sajadikhah, Seyed Sajad
Rostamizadeh, Mohsen
[J]. CHINESE JOURNAL OF CHEMISTRY, 2010, 28 (02) : 285 - 288
[32] One-pot synthesis of pyrimidines under solvent-free conditions
Ghorbani-Vaghei, Ramin
Karimi-Nami, Rahman
Toghraei-Semiromi, Zahra
Amiri, Mostafa
Salimi, Zahra
Ghavidel, Mehdi
[J]. COMPTES RENDUS CHIMIE, 2014, 17 (04) : 324 - 330
[33] NbCl5: an efficient catalyst for one-pot synthesis of α-aminophosphonates under solvent-free conditions
Hou, Jun-Tao
Gao, Jian-Wu
Zhang, Zhan-Hui
[J]. APPLIED ORGANOMETALLIC CHEMISTRY, 2011, 25 (01) : 47 - 53
[34] Benzyltriphenylphosphonium Chloride: An Efficient Catalyst for One-Pot Synthesis of Dihydropyrimidinones/thiones Under Solvent-Free Conditions
Alikarami, Mohammad
Moradi, Ronak
[J]. LETTERS IN ORGANIC CHEMISTRY, 2015, 12 (08) : 560 - 565
[35] Synthesis of thiohydantoins under one-pot three-component solvent-free conditions
Cao, Song
Zhu, Longjie
Zhao, Chuanmeng
Tang, Xiuhong
Sun, Huajun
Feng, Xin
Qian, Xuhong
[J]. MONATSHEFTE FUR CHEMIE, 2008, 139 (08): : 923 - 926
[36] Synthesis of thiohydantoins under one-pot three-component solvent-free conditions
Song Cao
Longjie Zhu
Chuanmeng Zhao
Xiuhong Tang
Huajun Sun
Xin Feng
Xuhong Qian
[J]. Monatshefte für Chemie - Chemical Monthly, 2008, 139
[37] β-Cyclodextrin nanosponge polymer: a basic and eco-friendly heterogeneous catalyst for the one-pot four-component synthesis of pyranopyrazole derivatives under solvent-free conditions
Nasab, Mina Jafari
Kiasat, Ali Reza
Zarasvandi, Raziyeh
[J]. REACTION KINETICS MECHANISMS AND CATALYSIS, 2018, 124 (02) : 767 - 778
[38] Solvent-free one-pot four-component synthesis of 2-aminomorpholines. Access to related diaminoalcohols
Regnier, Thomas
Berree, Fabienne
Lavastre, Olivier
Carboni, Bertrand
[J]. GREEN CHEMISTRY, 2007, 9 (02) : 125 - 126
[39] β-Cyclodextrin nanosponge polymer: a basic and eco-friendly heterogeneous catalyst for the one-pot four-component synthesis of pyranopyrazole derivatives under solvent-free conditions
Mina Jafari Nasab
Ali Reza Kiasat
Raziyeh Zarasvandi
[J]. Reaction Kinetics, Mechanisms and Catalysis, 2018, 124 : 767 - 778
[40] Solvent-Free Synthesis of Hydrazine-Substituted Enaminones via a One-Pot Four-Component Reaction
Alizadeh, Abdolali
Babaki, Mohadeseh
Zohreh, Nasrin
[J]. SYNTHESIS-STUTTGART, 2008, (20): : 3295 - 3298

← 1 2 3 4 5 →