Highly efficient one-pot four-component Kabachnik-Fields synthesis of novel α-amino phosphonates under solvent-free and catalyst-free conditions

被引：10

作者：

Rashid, Zahra ^{[1
]}

Naeimi, Hossein ^{[2
]}

Ghahremanzadeh, Ramin ^{[1
]}

机构：

[1] ACECR, Avicenna Res Inst, Nanobiotechnol Res Ctr, Tehran, Iran

[2] Univ Kashan, Fac Chem, Dept Organ Chem, Kashan 87317, Iran

来源：

RSC ADVANCES | 2015年 / 5卷 / 120期

关键词：

3-COMPONENT SYNTHESIS; ANTITUMOR-ACTIVITY; AMINOPHOSPHONATES; ACID; AMBIENT;

D O I：

10.1039/c5ra18311a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the present study, a simple and highly efficient protocol for the preparation of novel alpha-amino phosphonates is achieved based on the one-pot reaction of ninhydrin, 1,2-phenylenediamines, aniline derivatives, and dialkyl or diaryl phosphites, without using any catalyst under solvent-free conditions. The main advantages of the reaction are short reaction time, high yields, simple workup, and no need for further purification.

引用

页码：99148 / 99152

页数：5

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