The Tumor-Associated Marker, PVRL4 (Nectin-4), Is the Epithelial Receptor for Morbilliviruses

被引：44
|
作者：
Delpeut, Sebastien [1 ,2 ]
Noyce, Ryan S. [1 ,2 ]
Richardson, Christopher D. [1 ,2 ,3 ]
机构：
[1] Dalhousie Univ, Dept Microbiol & Immunol, Halifax, NS B3H 1X5, Canada
[2] Canadian Ctr Vaccinol, IWK Hlth Ctr, Halifax, NS B3H 1X5, Canada
[3] Dalhousie Univ, Dept Pediat, Halifax, NS B3K 6R8, Canada
来源：
VIRUSES-BASEL | 2014年 / 6卷 / 06期
基金：
加拿大健康研究院;
关键词：
morbillivirus; measles virus; canine distemper virus; peste des petits ruminants virus; nectin-4; PVRL4; epithelial receptor; cancer; CANINE-DISTEMPER VIRUS; PETITS-RUMINANTS VIRUS; COMPLEMENT-REGULATORY PROTEINS; HUMORAL IMMUNE-RESPONSES; UPPER RESPIRATORY-TRACT; MEASLES-VIRUS; V-DOMAIN; CELLULAR RECEPTOR; RHESUS-MONKEYS; BASOLATERAL SURFACE;
D O I：
10.3390/v6062268
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
PVRL4 (nectin-4) was recently identified as the epithelial receptor for members of the Morbillivirus genus, including measles virus, canine distemper virus and peste des petits ruminants virus. Here, we describe the role of PVRL4 in morbillivirus pathogenesis and its promising use in cancer therapies. This discovery establishes a new paradigm for the spread of virus from lymphocytes to airway epithelial cells and its subsequent release into the environment. Measles virus vaccine strains have emerged as a promising oncolytic platform for cancer therapy in the last ten years. Given that PVRL4 is a well-known tumor-associated marker for several adenocarcinoma (lung, breast and ovary), the measles virus could potentially be used to specifically target, infect and destroy cancers expressing PVRL4.
引用
收藏
页码：2268 / 2286
页数：19
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