Highly efficient three-component Strecker-type reaction catalyzed by MgI2 etherate under solvent-free conditions

被引：17
|
作者：
Li, Pengcheng [1 ]
Zhang, Yongdong [1 ]
Chen, Zhili [1 ]
Zhang, Xingxian [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310032, Zhejiang, Peoples R China
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 19期
基金：
中国国家自然科学基金;
关键词：
Strecker reaction; Aldehydes; Ketones; Amines; Trimethylsilyl cyanide; MgI2; etherate; Solvent-free condition; ONE-POT SYNTHESIS; CYANOHYDRIN TRIMETHYLSILYL ETHERS; ALPHA-AMINONITRILES; CARBONYL-COMPOUNDS; ACID CATALYST; MULTICOMPONENT REACTIONS; POTASSIUM PHTHALIMIDE; AMINES; CHLORIDE; REAGENT;
D O I：
10.1016/j.tetlet.2017.03.087
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A concise, straightforward and efficient method has been developed for the synthesis of alpha-aminonitriles by an one-pot three-component condensation of aldehydes or ketones, amines and trimethylsilyl cyanide catalyzed by MgI2 etherate under solvent-free conditions. This protocol has some advantages such as mild reaction condition, simple work-up, short reaction time and high product yields. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1854 / 1858
页数：5
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