NRG Oncology CC001: A phase III trial of hippocampal avoidance (HA) in addition to whole-brain radiotherapy (WBRT) plus memantine to preserve neurocognitive function (NCF) in patients with brain metastases (BM).

被引：16

作者：

Gondi, Vinai

Deshmukh, Snehal

Brown, Paul D.

Wefel, Jeffrey Scott

Tome, Wolfgang

Armstrong, Terri

Bruner, Deborah

Bovi, Joseph A.

Robinson, Cliff Grant

Khuntia, Deepak

Grosshans, David R.

Konski, Andre A.

Roberge, David

Kundapur, Vijayananda

Devisetty, Kiran

Shah, Sunjay A.

Usuki, Kenneth

Anderson, Bethany Marie

Mehta, Minesh P.

Kachnic, Lisa A.

机构：

[1] Northwestern Med Canc Ctr Warrenville, Warrenville, IL USA

[2] Northwestern Med Proton Ctr, Warrenville, IL USA

[3] NRG Oncol, Philadelphia, PA USA

[4] Mayo Clin, Rochester, MN USA

[5] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[6] Montefiore Med Ctr, 111 E 210th St, Bronx, NY 10467 USA

[7] NCI, Bethesda, MD 20892 USA

[8] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA

[9] Froedtert, Wauwatosa, WI USA

[10] Med Coll Wisconsin, Wauwatosa, WI USA

[11] Washington Univ, St Louis, MO 63110 USA

[12] East Bay Radiat Oncol Ctr, Castro Valley, CA USA

[13] Univ Penn, Chester, PA USA

[14] CHUM Hotel Dieu Montreal, Montreal, PQ, Canada

[15] Univ Saskatchewan, Saskatoon Canc Ctr, Dept Radiat Oncol, Saskatoon, SK, Canada

[16] McLaren Canc Inst Flint, Grand Blanc, MI USA

[17] Christiana Care Hlth Syst, Helen F Graham Canc Ctr & Res Inst, Newark, DE USA

[18] Univ Rochester, Med Ctr, Rochester, NY 14642 USA

[19] Univ Wisconsin, Madison, WI USA

[20] Baptist Hlth South Florida, Miami Canc Inst, Miami, FL USA

[21] Vanderbilt Univ, Med Ctr, Nashville, TN USA

[22] Vanderbilt Ingram Canc Ctr, Nashville, TN USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2019年 / 37卷 / 15期

关键词：

D O I：

10.1200/JCO.2019.37.15_suppl.2009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

2009

引用

页数：2

共 34 条

[1] NRG Oncology CC001 Neurocognitive Final Analysis: A Phase III Trial of Hippocampal Avoidance (HA) in Addition to Whole-Brain Radiotherapy (WBRT) Plus Memantine to Preserve Neurocognitive Function (NCF) in PatientsWith Brain Metastases (BM)
Wefel, Jeffrey S.
Pugh, Stephanie
Gondi, Vinai
Brown, Paul D.
Tome, Wolfgang
Armstrong, Terri S.
Bruner, Deborah
Bovi, Joseph
Robinson, Cliff
Khuntia, Deepak
Grosshans, David
Konski, Andre
Roberge, David
Kundapur, Vijayananda
Devisetty, Kiran
Shah, Sunjay
Usuki, Kenneth
Anderson, Bethany
Mehta, Minesh P.
Kachnic, Lisa
[J]. NEUROSURGERY, 2019, 66 : 137 - 138
[2] PRESERVATION OF NEUROCOGNITIVE FUNCTION (NCF) WITH HIPPOCAMPAL AVOIDANCE DURING WHOLE-BRAIN RADIOTHERAPY (WBRT) FOR BRAIN METASTASES: PRELIMINARY RESULTS OF PHASE III TRIAL NRG ONCOLOGY CC001
Gondi, Vinai
Pugh, Stephanie
Brown, Paul D.
Wefel, Jeffrey
Gilbert, Mark
Bovi, Joseph
Robinson, Cliff
Tammie, Benzinger
Tome, Wolfgang
Armstrong, Terri
Bruner, Deborah
Khuntia, Deepak
Grosshans, David
Konski, Andre
Robidoux, Andre
Kundapur, Vijayananda
Devisetty, Kiran
Shah, Sunjay
Usuki, Kenneth
Anderson, Bethany
Stea, Baldassarre
Yoon, Harold
Li, Jing
Laack, Nadia
Kruser, Tim
Chmura, Steven
Shi, Wenyin
Mehta, Minesh P.
Kachnic, Lisa
[J]. NEURO-ONCOLOGY, 2018, 20 : 172 - 172
[3] Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001
Brown, Paul D.
Gondi, Vinai
Pugh, Stephanie
Tome, Wolfgang A.
Wefel, Jeffrey S.
Armstrong, Terri S.
Bovi, Joseph A.
Robinson, Cliff
Konski, Andre
Khuntia, Deepak
Grosshans, David
Benzinger, Tammie L. S.
Bruner, Deborah
Gilbert, Mark R.
Roberge, David
Kundapur, Vijayananda
Devisetty, Kiran
Shah, Sunjay
Usuki, Kenneth
Anderson, Bethany Marie
Stea, Baldassarre
Yoon, Harold
Li, Jing
Laack, Nadia N.
Kruser, Tim J.
Chmura, Steven J.
Shi, Wenyin
Deshmukh, Snehal
Mehta, Minesh P.
Kachnic, Lisa A.
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (10) : 1019 - +
[4] Preservation of Neurocognitive Function (NCF) with Conformal Avoidance of the Hippocampus during Whole-Brain Radiotherapy (HA-WBRT) for Brain Metastases: Preliminary Results of Phase III Trial NRG Oncology CC001
Gondi, V.
Deshmukh, S.
Brown, P. D.
Wefel, J. S.
Tome, W. A.
Bruner, D. W.
Bovi, J. A.
Robinson, C. G.
Khuntia, D.
Grosshans, D. R.
Konski, A. A.
Roberge, D.
Kundapur, V.
Devisetty, K.
Shah, S. A.
Usuki, K. Y.
Anderson, B. M.
Mehta, M. P.
Kachnic, L. A.
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2018, 102 (05): : 1607 - 1607
[5] Significant Preservation of Neurocognitive Function (NCF) and Patient-Reported Symptoms with Hippocampal Avoidance (HA) during Whole-Brain Radiotherapy (WBRT) for Brain Metastases: Final Results of Nrg Oncology CC001
Gondi, V.
Pugh, S.
Brown, P. D.
Wefel, J. S.
Tome, W. A.
Armstrong, T. S.
Bruner, D. W.
Bovi, J. A.
Robinson, C. G.
Khuntia, D.
Grosshans, D. R.
Konski, A. A.
Roberge, D.
Kundapur, V.
Devisetty, K.
Shah, S. A.
Usuki, K. Y.
Anderson, B. M.
Mehta, M. P.
Kachnic, L. A.
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2019, 105 (01): : S12 - S13
[6] PRESERVATION OF NEUROCOGNITIVE FUNCTION & PATIENT-REPORTED SYMPTOMS WITH HIPPOCAMPAL AVOIDANCE (HA) DURING WHOLE-BRAIN RADIOTHERAPY (WBRT) FOR BRAIN METASTASES: LONG-TERM RESULTS OF NRG ONCOLOGY CC001
Armstrong, Terri
Deshmukh, Snehal
Brown, Paul
Gondi, Vinai
Benzinger, Tammy
Gilbert, Mark
Tome, Wolfgang
Wefel, Jeffrey
Bruner, Deborah
Roberge, David
Kundapur, Vijayananda
Devisetty, Kiran
Shah, Sunjay
Usuki, Kenneth
Baschnagel, Andrew
Stea, Baldassarre
Yoon, Harold
Li, Jing
Laack, Nadia
Mehta, Minesh
Kachnic, Lisa
[J]. NEURO-ONCOLOGY, 2019, 21 : 24 - 25
[7] IMPACT OF THE RATE OF RADIOGRAPHIC RESPONSE (RR) OF BRAIN METASTASES (BM) TO WHOLE BRAIN RADIATION THERAPY (WBRT) ON NEUROCOGNITIVE FUNCTION (NCF) ON NRG-CC001
Devisetty, Kiran
Pugh, Stephanie
Brown, Paul
Gondi, Vinai
Wefel, Jeffrey
Solanki, Abhishek
Kalapparambath, Tomy
Harmon, Grant
Saripalli, Anjali
Chou, Brian
Venkatesulu, Bhanu Prasad
Boike, Thomas
Kundapur, Vijayananda
Roberge, David
Bovi, Joseph
Mcgee, Mackenzie
Kruser, Tim
Baschnagel, Andrew
Usuki, Kenneth
Mehta, Minesh
Kachnic, Lisa
[J]. NEURO-ONCOLOGY, 2022, 24 : 197 - 197
[8] Estimation of Conditional Neurocognitive Function Failure (NCFF) Incidence in Patients Receiving Whole Brain Radiation Therapy (WBRT) for Brain Metastases (BM): Secondary Analysis of NRG CC001
Cherng, H. R. R.
Sun, K.
Bentzen, S. M.
Mishra, M. V.
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2023, 117 (02): : E94 - E94
[9] Hippocampal avoidance whole-brain radiotherapy without memantine in preserving neurocognitive function for brain metastases: a phase II blinded randomized trial
Yang, Wen-Chi
Chen, Ya-Fang
Yang, Chi-Cheng
Wu, Pei-Fang
Chan, Hsing-Min
Chen, Jenny Ling-Yu
Chen, Guann-Yiing
Cheng, Jason Chia-Hsien
Kuo, Sung-Hsin
Hsu, Feng-Ming
[J]. NEURO-ONCOLOGY, 2021, 23 (03) : 478 - 486
[10] Evaluating Heterogeneity of Hippocampal Avoidant Whole Brain Radiotherapy (HA-WBRT) Treatment Effect on Neurocognitive Function (NCF): Secondary Analysis of NRG-CC001
Cherng, H. R. R.
Sun, K.
Bentzen, S. M.
Gondi, V.
Mehta, M. P.
Mishra, M. V.
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2022, 114 (03): : S8 - S8

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