Mcl-1 inhibition enhances the proapoptotic effects of vemurafenib in melanoma cells

被引:0
|
作者
Sarif, Z. [1 ,2 ]
Dogan, A. [1 ]
Richtig, G. [3 ]
Fechner, H. [4 ]
Kreppel, F. [2 ]
Eberle, J. [1 ]
机构
[1] Charite Univ Med Berlin, Berlin, Germany
[2] Univ Witten Herdecke, Witten, Germany
[3] Med Univ Graz, Graz, Austria
[4] Tech Univ Berlin, Fachgebiet Angew Biochem, Berlin, Germany
关键词
D O I
暂无
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
P216
引用
收藏
页码:E106 / E106
页数:1
相关论文
共 50 条
  • [41] Microrna-Mediated MCL-1 Silencing in Melanoma Cells Enhances the Pro-Apoptotic Potential of BRAF and ERK 1/2 Pathway Inhibitors
    Sarif, Zina
    Dogan, Aybige
    Eberle, Juergen
    ONCOLOGY RESEARCH AND TREATMENT, 2020, 43 : 244 - 244
  • [42] MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex
    Konopleva, M.
    Milella, M.
    Ruvolo, P.
    Watts, J. C.
    Ricciardi, M. R.
    Korchin, B.
    McQueen, T.
    Bornmann, W.
    Tsao, T.
    Bergamo, P.
    Mak, D. H.
    Chen, W.
    McCubrey, J.
    Tafuri, A.
    Andreeff, M.
    LEUKEMIA, 2012, 26 (04) : 778 - 787
  • [43] The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006
    Chunrong Yu
    Laura M Bruzek
    Xue Wei Meng
    Gregory J Gores
    Christopher A Carter
    Scott H Kaufmann
    Alex A Adjei
    Oncogene, 2005, 24 : 6861 - 6869
  • [44] MEK/ERK and MCL-1 inhibition synergistically reverse apoptosis resistance in colon cancer cells with BRAF(V600E)-mediated MCL-1 upregulation
    Kawakami, Hisato
    Huang, Shengbing
    Sinicrope, Frank A.
    CANCER RESEARCH, 2016, 76
  • [45] Repression of Mcl-1 and disruption of the Mcl-1/Bak interaction in myeloma cells couple ER stress to mitochondrial apoptosis
    Gomez-Bougie, Patricia
    Halliez, Maxime
    Moreau, Philippe
    Pellat-Deceunynck, Catherine
    Amiot, Martine
    CANCER LETTERS, 2016, 383 (02) : 204 - 211
  • [46] Reduction of Mcl-1 expression by antisense oligonucleotides chemosensitizes human melanoma
    Thallinger, C
    Wolschek, M
    Günsberg, P
    Maierhofer, H
    Wacheck, V
    Wolff, K
    Pehamberger, H
    Selzer, E
    Jansen, B
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2002, 119 (01) : 347 - 347
  • [47] Inhibition of cyclin E1 sensitizes hepatocellular carcinoma cells to regorafenib by mcl-1 suppression
    Xu, Jianliang
    Huang, Fei
    Yao, Zhicheng
    Jia, Changchang
    Xiong, Zhiyong
    Liang, Hao
    Lin, Nan
    Deng, Meihai
    CELL COMMUNICATION AND SIGNALING, 2019, 17 (1)
  • [48] The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006
    Yu, CR
    Bruzek, LM
    Meng, XW
    Gores, GJ
    Carter, CA
    Kaufmann, SH
    Adjei, AA
    ONCOGENE, 2005, 24 (46) : 6861 - 6869
  • [49] RNAi-Mediated Inhibition of Mcl-1 Expression Enhances Apoptosis in Imatinib-Treated CML Progenitors
    Chu, Su
    Bhatia, Ravi
    BLOOD, 2011, 118 (21) : 725 - 725
  • [50] Inhibition of cyclin E1 sensitizes hepatocellular carcinoma cells to regorafenib by mcl-1 suppression
    Jianliang Xu
    Fei Huang
    Zhicheng Yao
    Changchang Jia
    Zhiyong Xiong
    Hao Liang
    Nan Lin
    Meihai Deng
    Cell Communication and Signaling, 17