Identification of inhibitors for UDP-galactopyranose mutase

被引：86
|
作者：
Soltero-Higgin, M
Carlson, EE
Phillips, JH
Kiessling, LL
机构：
[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA
[2] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 34期
关键词：
D O I：
10.1021/ja048017v
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The flavoenzyme uridine 5′-diphosphate (UDP)-galactopyranose mutase (UGM) plays a key role in the cell wall biosynthesis of many pathogens, including Mycobacterium tuberculosis. Using a synthetic fluorescent ligand, we screened 16000 compounds in a fluorescence polarization assay. Effective inhibitors of UGM were identified. Copyright © 2004 American Chemical Society.
引用
收藏
页码：10532 / 10533
页数：2
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