Evaluation of HLA-G, HLA-E, and PD-L1 proteins in oral osteosarcomas

被引：21
|
作者：
Costa Arantes, Diego Antonio [1 ]
Goncalves, Andreia Souza [1 ]
Jham, Bruno Correia [2 ]
Barroso Duarte, Eliza Carla [3 ]
de Paula, Elbio Candido [4 ]
de Paula, Henrique Moura [4 ,5 ]
Mendonca, Elismauro Francisco [1 ,6 ]
Batista, Aline Carvalho [1 ]
机构：
[1] Univ Fed Goias, Sch Dent, Dept Stomatol Oral Pathol, Goiania, Go, Brazil
[2] Midwestern Univ, Coll Dent Med Illinois, Downers Grove, IL 60515 USA
[3] Univ Brasilia, Sch Med, Dept Pathol, Brasilia, DF, Brazil
[4] Assoc Canc Combat Goias, Araujo Jorge Hosp, Div Anat Pathol, Goiania, Go, Brazil
[5] Univ Fed Goias, Sch Med, Dept Pathol & Med Lab, Goiania, Go, Brazil
[6] Assoc Canc Combat Goias, Araujo Jorge Hosp, Head & Neck Div, Goiania, Go, Brazil
来源：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY | 2017年 / 123卷 / 06期
关键词：
SQUAMOUS-CELL CARCINOMA; PROGRAMMED DEATH LIGAND-1; TUMOR MICROENVIRONMENT; PROGNOSTIC-FACTORS; UNTREATED MELANOMA; ANTIBODY BLOCKADE; CANCER PATIENTS; IMMUNE ESCAPE; NECK SARCOMAS; LUNG-CANCER;
D O I：
10.1016/j.oooo.2016.12.002
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Objective. The aim of this study was to investigate the expression of human leukocyte antigens (HLAs) G and E and programmed death-ligand 1 (PD-L1) in oral osteosarcoma (OO) (n = 13). The relationship between the expression of these molecules and histologic grading and metastasis was also evaluated. Study Design. HLA-G, HLA-E, and PD-L1 were identified by immunohistochemistry. Samples of normal bone tissue (n = 6) were used as controls. The sections were evaluated using a semiquantitative scoring system with an immunoreactive score, where a score of 0 was considered absent, <= 2 was low, and > 2 was high expression. Results. We identified high expression of HLA-G, HLA-E, and PD-L1 by malignant osteoblastic cells in 69.2% of OO cases, which was statistically higher than that in controls (P < .05). Overexpression of these proteins was identified in 8 of 11 samples of high-grade and 1 of 2 samples of low-grade OO. Additionally, 66.6% of patients with metastases (n = 4) and 71.4% of patients without metastases (n = 5) had high expression of HLA-G, HLA-E, and PD-L1 in tumor samples (P > .05). Conclusion. OO had high expression of HLA-G, HLA-E, and PD-L1 irrespective of clinicopathologic parameters, including histologic grading and metastasis.
引用
收藏
页码：E188 / E196
页数：9
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