Alcohol tolerance in rats submitted to different periods of chronic and acute ethanol intake

The development of tolerance to the effects of ethanol is not uniform and may vary according to the actual and previous pattern Of Consumption. In this experiment we assessed body temperature and the recovery of two reflexes after a high dose of ethanol in rats submitted to chronic and acute ethanol consumption. Animals were previously Submitted to chronic or acute alcohol consumption from postnatal day 2 1 until postnatal days 56 and 84. On the testing days, the animals received a single dose of 25% ethanol (5 g/kg, i.p.) or the same amount of saline solution. The results showed that animals were affected in the day 56 to a greater extent than in the day 84 by chronic heavy consumption of ethanol Solution. With moderate and acute ethanol consumption, the 56-day-old animals developed greater tolerance. However. tolerance was not developed for the motor-impairing effects, since all groups required a long time to recover reflexes.