Exploration of a β-cyclodextrin clicked chiral stationary phase in high-performance liquid chromatography

被引：16
|
作者：
Zhang, Shaopeng [1 ]
Wang, Huanhuan [1 ]
Tang, Jian [1 ]
Wang, Wei [2 ]
Tang, Weihua [1 ]
机构：
[1] Nanjing Univ Sci & Technol, Minist Educ, Key Lab Soft Chem & Funct Mat, Nanjing 210094, Jiangsu, Peoples R China
[2] China Pharmaceut Univ, Dept Analyt Chem, Nanjing 211198, Jiangsu, Peoples R China
来源：
ANALYTICAL METHODS | 2014年 / 6卷 / 07期
基金：
高等学校博士学科点专项科研基金; 中国国家自然科学基金;
关键词：
SEPARATION; RECOGNITION; CHEMISTRY;
D O I：
10.1039/c3ay42193g
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The baseline enantioseparation of 19 racemic drugs including ondansetron, citalopram, galanthamine base, pregabalin, timolol, atenolol, tropicamide, ephedrine hydrochloride, flavanoids and aryl alcohols has been successfully achieved with a cyclodextrin clicked chiral stationary phase in high performance liquid chromatography. The best separation results were presented under optimized conditions. The effect of organic modifiers including methanol and acetonitrile on the enantioseparation of racemates was also studied. Chiral resolutions of 4.19 and 4.42 were achieved for citalopram and tropicamide, respectively.
引用
收藏
页码：2034 / 2037
页数：4
相关论文
共 50 条
  • [31] Characterization of derivatized cellulose coated zirconia as chiral stationary phase by high-performance liquid chromatography
    Dan, HJ
    Han, XQ
    Liu, CH
    Li, YM
    Chen, LR
    CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2003, 31 (08) : 901 - 905
  • [32] AN AMYLOPECTIN TRIS(PHENYLCARBAMATE) CHIRAL STATIONARY-PHASE FOR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    FELIX, G
    ZHANG, T
    HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY, 1993, 16 (06): : 364 - 367
  • [33] Enantioseparation using alkoxyphenylcarbamates of cellulose and amylose as chiral stationary phase for high-performance liquid chromatography
    Yamamoto, C
    Inagaki, S
    Okamoto, Y
    JOURNAL OF SEPARATION SCIENCE, 2006, 29 (06) : 915 - 923
  • [34] DIRECT RESOLUTION OF ENANTIOMERS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ON A BONDED CHIRAL STATIONARY PHASE
    LOCHMULLER, CH
    RYALL, RR
    JOURNAL OF CHROMATOGRAPHY, 1978, 150 (02): : 511 - 514
  • [35] A WIDELY USEFUL CHIRAL STATIONARY PHASE FOR THE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY SEPARATION OF ENANTIOMERS
    PIRKLE, WH
    FINN, JM
    SCHREINER, JL
    HAMPER, BC
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (13) : 3964 - 3966
  • [36] Enantiomeric separation of d-/l-norepinephrine and -epinephrine by high-performance liquid chromatography with a β-cyclodextrin type chiral stationary phase
    Fukushima, T
    Murayama, K
    Santa, T
    Homma, H
    Imai, K
    BIOMEDICAL CHROMATOGRAPHY, 1998, 12 (01) : 1 - 3
  • [37] Enantioseparation tuned by solvent polarity on a β-cyclodextrin clicked chiral stationary phase
    Tang, Jian
    Pang, Limin
    Zhou, Jie
    Tang, Weihua
    JOURNAL OF SEPARATION SCIENCE, 2015, 38 (18) : 3137 - 3144
  • [38] Enantiomeric Separation of Chiral Amines and Amino Alcohols Using Acetylated beta-Cyclodextrin Stationary Phase by High-Performance Liquid Chromatography
    Nishioka, Ryota
    Harada, Syuji
    CHROMATOGRAPHY, 2016, 37 (02) : 65 - 71
  • [39] Enantiomeric resolution of (±)-licarin A by high-performance liquid-chromatography using a chiral stationary phase
    Pereira, Ana Carolina
    Magalhaes, Lizandra G.
    Januario, Ana Helena
    Pauletti, Patricia M.
    Cunha, Wilson Roberto
    Bastos, Jairo Kenupp
    Nanayakkara, Dhammika N. P.
    e Silva, Marcio Luis A.
    JOURNAL OF CHROMATOGRAPHY A, 2011, 1218 (39) : 7051 - 7054
  • [40] Enantiomeric separation of d-/l-norepinephrine and -epinephrine by high-performance liquid chromatography with a β-cyclodextrin type chiral stationary phase
    Fukushima, Takeshi
    Murayama, Katsuhisa
    Santa, Tomofumi
    Homma, Hiroshi
    Imai, Kazuhiro
    Biomedical Chromatography, 12 (01): : 1 - 3
12345