Amino acids as regulators of cell signalling

被引：2

作者：

Walrand, Stephane ^{[1
]}

Guillet, Christelle ^{[1
]}

Salles, Jerome ^{[1
]}

Tardif, Nicolas ^{[1
]}

Maurin, Anne-Catherine

Fafournoux, Pierre

Cano, Noel ^{[1
,2
,3
]}

Boirie, Yves ^{[1
,2
,3
]}

机构：

[1] CRNH Auvergne, Equipe Adapt Metab Musculaire, Unite Nutr Humain, Lab Nutr Humaine,UMR 1019, F-63009 Clermont Ferrand 1, France

[2] Equipe Genes & Nutriments, Inra Theix UMR 1019, Unite Nutr Humaine, F-63122 St Genes Champanelle, France

[3] CHU Clermont Ferrand, Serv Nutr Clin, F-63000 Clermont Ferrand, France

来源：

NUTRITION CLINIQUE ET METABOLISME | 2008年 / 22卷 / 04期

关键词：

Amino acids; Muscle; mTOR; CHOP; mGCN2/ATF4;

D O I：

10.1016/j.nupar.2008.10.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Amino acids (AA) are involved in the regulation of many intracellular biochemical pathways. This signalling role has been studied mostly in skeletal muscle, where some AA Such as leucine and citrulline, are particularly active in promoting protein synthesis. Several proteins involved in protein translation are activated by AA including a protein called mTOR. AA are also involved in the control of gene expression via an amino acid regulatory element (AARE) found in the promoter of several genes such as CHOP. The modulation of gene expression by AA is based on a complex mechanism involving a protein kinase GCN2 and the transcriptional factors ATE At a physiological level, the activation of this pathway allows, through a neural circuit, to inhibit food intake when AA composition in food is unbalanced. (C) 2008 Elsevier Masson SAS. Tous droits reserves

引用

页码：161 / 167

页数：7

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