Genome Wide Analysis of Sex Difference in Gene Expression Profiles of Bone Formations Using sfx Mice and BXD RI Strains

被引：2
|
作者：
Huang, Yue [1 ]
Zhu, Xiaodong [2 ]
Wang, Lishi [1 ,3 ]
Liu, Xiaoyun [1 ]
Lu, Lu [4 ]
Gu, Weikuan [1 ]
Jiao, Yan [1 ,2 ]
机构：
[1] Univ Tennessee, Hlth Sci Ctr, Dept Orthoped Surg & BME, Memphis, TN 38163 USA
[2] Mudanjiang Med Coll, Mudanjiang City 157001, Heilongjiang, Peoples R China
[3] Inner Mongolia Med Coll, Dept Basic Res, Hohhot 010110, Inner Mongolia, Peoples R China
[4] Univ Tennessee, Hlth Sci Ctr, Dept Anat & Neurobiol, Memphis, TN 38163 USA
来源：
SCIENTIFIC WORLD JOURNAL | 2014年
基金：
美国国家卫生研究院; 中国国家自然科学基金;
关键词：
VITAMIN-C; MINERAL DENSITY; ASCORBIC-ACID; POLYMORPHISMS; STRESS; MUSCLE; REGION; MODEL;
D O I：
10.1155/2014/584910
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The objective of this study is to identify sex differentially expressed genes in bone using a mouse model of spontaneous fracture, sfx, which lacks the gene for L-gulonolactone oxidase (Gulo), a key enzyme in the ascorbic acid (AA) synthesis pathway. We first identified the genes that are differentially expressed in the femur between female and male in sfx mice. We then analyzed the potential gene network among those differentially expressed genes with whole genome expression profiles generated using spleens of female and male mice of a total of 67 BXD (C57BL/6J X DBA/2J) recombinant inbred (RI) and other strains. Our result indicated that there was a sex difference in the whole genome profiles in sfx mice as measured by the proportion of up-and downregulated genes. Several genes in the pathway of bone development are differentially expressed between the male and female of sfx mice. Comparison of gene network of up-and downregulated bone relevant genes also suggests a sex difference.
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页数：11
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