Biological Aspects of Cancer Health Disparities

被引：11
|
作者：
Freedman, Jennifer A. [1 ,2 ]
Al Abo, Muthana [1 ]
Allen, Tyler A. [1 ]
Piwarski, Sean A. [2 ]
Wegermann, Kara [3 ]
Patierno, Steven R. [1 ,2 ]
机构：
[1] Duke Univ, Sch Med, Duke Canc Inst, Durham, NC 27710 USA
[2] Duke Univ, Sch Med, Dept Med, Div Med Oncol, Durham, NC 27710 USA
[3] Duke Univ Hlth Syst, Div Gastroenterol, Durham, NC 27710 USA
来源：
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021 | 2021年 / 72卷
关键词：
ancestry-related biology; mutation; gene fusion; aggregate gene expression; RNA splicing; microRNA; long noncoding RNA; epigenetics; immuno-oncology; precision medicine; AFRICAN-AMERICAN; PROSTATE-CANCER; RACIAL/ETHNIC DISPARITIES; BREAST-CANCER; LUNG-CANCER; SOMATIC MUTATIONS; RACE; GENES; ADENOCARCINOMA; IDENTIFICATION;
D O I：
10.1146/annurev-med-070119-120305
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Racial and ethnic disparities span the continuum of cancer care and are driven by a complex interplay among social, psychosocial, lifestyle, environmental, health system, and biological determinants of health. Research is needed to identify these determinants of cancer health disparities and to develop interventions to achieve cancer health equity. Herein, we focus on the overall burden of ancestry-related molecular alterations, the functional significance of the alterations in hallmarks of cancer, and the implications of the alterations for precision oncology and immuno-oncology. In conclusion, we reflect on the importance of estimating ancestry, improving diverse racial and ethnic participation in cancer clinical trials, and examining the intersection among determinants of cancer health disparities.
引用
收藏
页码：229 / 241
页数：13
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