A New Isochroman Derivative from the Marine Fungus Phomopsis sp (No. Gx-4)

被引：8
|
作者：
Yang, Jian Xiang [1 ,3 ]
Qiu, ShengXiang [1 ]
She, Zhigang [2 ]
Lin, Yongcheng [2 ]
机构：
[1] Chinese Acad Sci, South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China
[3] Guilin Normal Coll, Dept Chem & Engn, Guilin 541002, Guangxi, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2014年 / 50卷 / 03期
基金：
中国国家自然科学基金;
关键词：
natural product; isochroman derivative; marine fungus; bioassays; NMR assignment; CHINA SEA COAST; MANGROVE FUNGUS; METABOLITES;
D O I：
10.1007/s10600-014-0976-y
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new isochroman, (3R,4S)-3,4-dihydro-8-hydroxy-4-methoxy-3-methylisocoumarin (1), and three known compounds were isolated from the marine fungus Phomopsis sp. (No. Gx-4). Their structures were determined by spectroscopic methods, mainly 1D and 2D NMR. Primary bioassays and preliminary pharmacological tests revealed that compounds 1 and 3 can accelerate the growth of subintestinal vessel plexus (SIV) branches markedly, but compounds 2 and 4 can inhibit their growth.
引用
收藏
页码：424 / 426
页数：3
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