Novel Three-Component Annulation for the Synthesis of 2,4,6-Triarylpyrimidines under Solvent-Free and Catalyst-Free Conditions

被引：0
|
作者：
Ding, Yuxin [1 ,2 ]
Ma, Yongmin [1 ,2 ]
Chen, Jing [1 ]
机构：
[1] Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China
[2] Taizhou Univ, Sch Pharmaceut & Chem Engn, Taizhou 318000, Zhejiang, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 40卷 / 12期
关键词：
catalyst-free; solvent-free; one-pot; three-component reaction; 2,4,6-triarylpyrimidine; ANTITUMOR-ACTIVITY; PYRIMIDINES; DESIGN;
D O I：
10.6023/cjoc202005078
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2,4,6-Triarylpyrimidines were synthesized via a simple, efficient, one-pot, three-component reaction from 1,3-dikeones, benzaldehydes and ammonium acetate under solvent-free and catalyst-free conditions in good to excellent yields. This "green" methodology provides an eco-friendly protocol for the construction of the pyrimidine framework.
引用
收藏
页码：4357 / 4363
页数：7
相关论文
共 39 条
  • [1] Microwave-assisted simple, one-pot, four-component synthesis of 2,4,6-triarylpyrimidines under solvent-free conditions
    Adib, Mehdi
    Mahmoodi, Niusha
    Mahdavi, Mohammad
    Bijanzadeh, Hamid Reza
    [J]. TETRAHEDRON LETTERS, 2006, 47 (52) : 9365 - 9368
  • [2] Synthesis of 2,4,6-trisubstituted pyrimidines as antimalarial agents
    Agarwal, A
    Srivastava, K
    Puri, SK
    Chauhan, PMS
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (15) : 4645 - 4650
  • [3] Antimalarial activity of 2,4,6-trisubstituted pyrimidines
    Agarwal, A
    Srivastava, K
    Puri, SK
    Chauhan, PMS
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (07) : 1881 - 1883
  • [4] Designed self-generation of an extended helical structure from an achiral polyheterocyclic strand
    Bassani, DM
    Lehn, JM
    Baum, G
    Fenske, D
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1997, 36 (17): : 1845 - 1847
  • [5] Brown D.J., 1994, PYRIMIDINES, V52
  • [6] Bule MH, 2019, J CHEM PHARM RES, V11, P27
  • [7] Design, synthesis and SAR study of novel sulfonylurea derivatives containing arylpyrimidine moieties as potential anti-phytopathogenic fungal agents
    Chen, Wei
    Li, Yuxin
    Zhou, Yunyun
    Ma, Yi
    Li, Zhengming
    [J]. CHINESE CHEMICAL LETTERS, 2019, 30 (12) : 2160 - 2162
  • [8] Iron Catalysis for Modular Pyrimidine Synthesis through β-Ammoniation/Cyclization of Saturated Carbonyl Compounds with Amidines
    Chu, Xue-Qiang
    Cao, Wen-Bin
    Xu, Xiao-Ping
    Ji, Shun-Jun
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2017, 82 (02): : 1145 - 1154
  • [9] A Sustainable Multicomponent Pyrimidine Synthesis
    Deibl, Nicklas
    Ament, Kevin
    Kempe, Rhett
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2015, 137 (40) : 12804 - 12807
  • [10] Acid-Catalyzed Pseudo Five-Component Annulation for a General One-Pot Synthesis of 2,4,6-Triaryl Pyrimidines
    Ding, Yuxin
    Ma, Renchao
    Hider, Robert C.
    Ma, Yongmin
    [J]. ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2020, 9 (02) : 242 - 246
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