Preparation of 5-aryl furfurals and aryl thiophene-2-carboxaldehydes via palladium-catalyzed C-C bond formation in aqueous media

被引：70
|
作者：
Bussolari, JC [1 ]
Rehborn, DC [1 ]
机构：
[1] RW Johnson Pharmaceut Res Inst, Raritan, NJ 08869 USA
来源：
ORGANIC LETTERS | 1999年 / 1卷 / 07期
关键词：
D O I：
10.1021/ol990708m
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] A series of 5-aryl furfurals and aryl thiophene-2-carboxaldehydes was synthesized. To this end, efficient and effective palladium-catalyzed C-C bond-forming reactions were carried out at room temperature in aqueous media. This mild process allowed the cross-coupling reaction of the bromides to occur in the presence of electrophilic functional groups, which is a valuable advantage over previously reported methods.
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收藏
页码：965 / 967
页数：3
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