PD-1 and CTLA-4: Two checkpoints, one pathway?

被引:17
|
作者
Walker, Lucy S. K. [1 ]
机构
[1] UCL, Div Infect & Immun, Inst Immun & Transplantat, Royal Free Campus, London NW3 2PF, England
基金
英国医学研究理事会;
关键词
T-CELLS; CD28;
D O I
10.1126/sciimmunol.aan3864
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
[No abstract available]
引用
收藏
页数:2
相关论文
共 50 条
  • [41] Evaluation of PD-1/PD-L1 and CTLA-4 immune checkpoints and angiogenic activity in ovarian cancer after oncotherad immunotherapy associated to erythropoietin.
    de Souza, Bianca Ribeiro
    Oliveira, Gabriela
    Leme, Giovana
    Reis, Ianny Brum
    Tossini Cabral, Felippe Augusto
    Baggio de Paula, Juliane Lima
    da Silva Santos, Daniel Henrique
    Felizzola, Claudia Ronca
    Duran, Nelson
    Favaro, Wagner Jose
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16) : E17560 - E17560
  • [42] PD-L1/PD-1 and CTLA-4 Expression in Equine Penile Squamous Cell Carcinomas
    Porcellato, Ilaria
    Mecocci, Samanta
    Brachelente, Chiara
    Cappelli, Katia
    Armando, Federico
    Tognoloni, Alessia
    Chiaradia, Elisabetta
    Stefanetti, Valentina
    Mechelli, Luca
    Pepe, Marco
    Gialletti, Rodolfo
    Passeri, Benedetta
    Ghelardi, Alessandro
    Razzuoli, Elisabetta
    ANIMALS, 2021, 11 (07):
  • [43] Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups
    Lawrence P. Andrews
    Hiroshi Yano
    Dario A. A. Vignali
    Nature Immunology, 2019, 20 : 1425 - 1434
  • [44] Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups
    Andrews, Lawrence P.
    Yano, Hiroshi
    Vignali, Dario A. A.
    NATURE IMMUNOLOGY, 2019, 20 (11) : 1425 - 1434
  • [45] PD-L1, PD-1, and CTLA-4 Expression in Invasive Breast Cancer in Young Women
    Obeidin, Farres
    Pincus, Jennifer
    Siziopikou, K. P.
    Blanco, Luis
    LABORATORY INVESTIGATION, 2019, 99
  • [46] GENERALIZABILITY OF POTENTIAL BIOMARKERS OF RESPONSE TO CTLA-4 AND PD-1 BLOCKADE THERAPY IN CANCER
    Bortone, Dante
    Vensko, Steven
    Entwistle, Sarah
    Cogdill, Alexandria
    Monette, Anne
    Najjar, Yana
    Sweis, Randy
    Tschernia, Nicholas
    Wennerberg, Erik
    Bommareddy, Praveen
    Haymaker, Cara
    Khan, Uqba
    McGee, Heather
    Park, Wungki
    Sater, Houssein
    Spencer, Christine
    Ascierto, Maria
    Barsan, Valentin
    Popat, Vinita
    Valpione, Sara
    Wells, Danny
    Thorsson, Vesteinn
    Zappasodi, Roberta
    Rudqvist, Nils
    Vincent, Benjamin
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 : A46 - A47
  • [47] Expression of PD-1 and CTLA-4 Are Negative Prognostic Markers in Renal Cell Carcinoma
    Kahlmeyer, Andreas
    Stoehr, Christine G.
    Hartmann, Arndt
    Goebell, Peter J.
    Wullich, Bernd
    Wach, Sven
    Taubert, Helge
    Erlmeier, Franziska
    JOURNAL OF CLINICAL MEDICINE, 2019, 8 (05)
  • [48] Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade
    Andrews, Miles C.
    Duong, Connie P. M.
    Gopalakrishnan, Vancheswaran
    Iebba, Valerio
    Chen, Wei-Shen
    Derosa, Lisa
    Khan, Md Abdul Wadud
    Cogdill, Alexandria P.
    White, Michael G.
    Wong, Matthew C.
    Ferrere, Gladys
    Fluckiger, Aurelie
    Roberti, Maria P.
    Opolon, Paule
    Alou, Maryam Tidjani
    Yonekura, Satoru
    Roh, Whijae
    Spencer, Christine N.
    Curbelo, Irina Fernandez
    Vence, Luis
    Reuben, Alexandre
    Johnson, Sarah
    Arora, Reetakshi
    Morad, Golnaz
    Lastrapes, Matthew
    Baruch, Erez N.
    Little, Latasha
    Gumbs, Curtis
    Cooper, Zachary A.
    Prieto, Peter A.
    Wani, Khalida
    Lazar, Alexander J.
    Tetzlaff, Michael T.
    Hudgens, Courtney W.
    Callahan, Margaret K.
    Adamow, Matthew
    Postow, Michael A.
    Ariyan, Charlotte E.
    Gaudreau, Pierre-Olivier
    Nezi, Luigi
    Raoult, Didier
    Mihalcioiu, Catalin
    Elkrief, Arielle
    Pezo, Rossanna C.
    Haydu, Lauren E.
    Simon, Julie M.
    Tawbi, Hussein A.
    McQuade, Jennifer
    Hwu, Patrick
    Hwu, Wen-Jen
    NATURE MEDICINE, 2021, 27 (08) : 1432 - +
  • [49] Targeting CTLA-4 in cancer: Is it the ideal companion for PD-1 blockade immunotherapy combinations?
    De Silva, Pushpamali
    Aiello, Marco
    Gu-Trantien, Chunyan
    Migliori, Edoardo
    Willard-Gallo, Karen
    Solinas, Cinzia
    INTERNATIONAL JOURNAL OF CANCER, 2021, 149 (01) : 31 - 41
  • [50] EXPRESSION OF PD-1 AND CTLA-4 IS INCREASED DURING SYMPTOMATIC PHASE OF ACUTE HEPATITIS A
    Kim, C. W.
    Cho, H.
    Kim, H. Y.
    Lee, S. W.
    Jang, J. W.
    Choi, J. Y.
    Yoon, S. K.
    Lee, C. D.
    JOURNAL OF HEPATOLOGY, 2013, 58 : S140 - S141