Two- and three-locus tests for linkage analysis using recombinant inbred lines

被引：17
|
作者：
Martin, Olivier C. [1 ]
Hospital, Frederic [1 ]
机构：
[1] INRA, Stn Genet Vegetale, UMR Genet Vegetale, F-91190 Gif Sur Yvette, France
来源：
GENETICS | 2006年 / 173卷 / 01期
关键词：
D O I：
10.1534/genetics.105.047175
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We consider fixed recombinant inbred lines (RILs) derived either by selfing or by full-sib mating; when applicable, we also consider intermated recombinant inbreds (IRIs). First, we show that the usual estimate of recombination fraction based on RIL data is biased, and we provide an estimate where the major part of that bias is removed. Second, we derive simple formulas to compute the frequencies of genotypes at three loci in RILs. We describe the nonindependence of multiple recombinations arising in RIL recombination data even though there may be no interference in each meiosis. Finally, we give formulas for interference tests, gene mapping, or QTL detection in RIL Populations.
引用
收藏
页码：451 / 459
页数：9
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