The HBZ gene, a key player in HTLV-1 pathogenesis

被引：128
|
作者：
Matsuoka, Masao [4 ]
Green, Patrick L. [1 ,2 ,3 ]
机构：
[1] Ohio State Univ, Ctr Retrovirus Res, Dept Vet Biosci & Mol Virol, Columbus, OH 43210 USA
[2] Ohio State Univ, Ctr Comprehens Canc, Dept Med Genet, Columbus, OH 43210 USA
[3] Ohio State Univ, Solove Res Inst, Columbus, OH 43210 USA
[4] Kyoto Univ, Inst Virus Res, Lab Virus Control, Kyoto 6068507, Japan
来源：
RETROVIROLOGY | 2009年 / 6卷
基金：
美国国家卫生研究院;
关键词：
T-CELL LEUKEMIA; BZIP FACTOR HBZ; ZIPPER FACTOR HBZ; NF-KAPPA-B; IN-VIVO; TRANSCRIPTIONAL ACTIVITY; ANTISENSE TRANSCRIPTS; VIRAL TRANSCRIPTION; TERMINAL REPEAT; C-JUN;
D O I：
10.1186/1742-4690-6-71
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL) and is also associated with a variety of lymphocyte-mediated diseases. The HTLV-1 basic leucine zipper (HBZ) gene, found to be consistently expressed in ATL, has recently been the subject of intensive research efforts. In this review, we summarize recent findings about HBZ and discuss its roles and functions not only in the virus life cycle, but also in HTLV-1 disease pathogenesis.
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页数：8
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