Predictive and Prognostic Significance of Tumor-infiltrating Lymphocytes in Patients with Breast Cancer Treated with Neoadjuvant Systemic Therapy

被引：0
|
作者：
Melichar, Bohuslav [1 ]
Studentova, Hana [1 ]
Kalabova, Hana [1 ]
Vitaskova, Denisa [1 ]
Cermakova, Petra [2 ]
Hornychova, Helena [2 ]
Ryska, Ales [2 ]
机构：
[1] Palacky Univ, Med Sch & Teaching Hosp, Dept Oncol, Olomouc 77520, Czech Republic
[2] Charles Univ Prague, Med Sch & Teaching Hosp, Fingerland Inst Pathol, Hradec Kralove, Czech Republic
来源：
ANTICANCER RESEARCH | 2014年 / 34卷 / 03期
关键词：
Breast cancer; targeted therapy; tumor-infiltrating lymphocytes; review; PATHOLOGICAL COMPLETE RESPONSE; REGULATORY T-CELLS; GENE-EXPRESSION PROFILES; SURGICAL ADJUVANT BREAST; HUMAN SOLID TUMORS; PREOPERATIVE CHEMOTHERAPY; ENDOMETRIAL CANCER; URINARY NEOPTERIN; IMMUNE ACTIVATION; RANDOMIZED-TRIAL;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Despite the progress of tailored therapeutic strategies in patients with breast cancer, there is an unmet medical need for additional biomarkers that would guide therapy, including the administration of targeted agents. It has been demonstrated that the presence of tumor-infiltrating lymphocytes (TILs) is associated with prognosis in patients with early breast cancer. Moreover, TIL counts were shown to predict outcome of neoadjuvant chemotherapy. The neoadjuvant setting is increasingly used to assess the efficacy of new systemic therapies, and TILs are promising as a biomarker reflecting the immune response to tumor. Future studies should investigate on the integration of TILs as predictive biomarkers in patients treated with targeted- agents.
引用
收藏
页码：1115 / 1125
页数：11
相关论文
共 50 条
  • [31] The Prognostic Significance of Infiltrating Lymphocytes in Patients with Pancreatic Ductal Adenocarcinoma Treated with Neoadjuvant Therapy
    Nejati, Reza
    Halperin, Daniel M.
    Goldstein, Jennifer B.
    Wang, Hua
    Rashid, Asif
    Katz, Matthew H.
    Lee, Jeffrey E.
    Fleming, Jason B.
    Canales, Jaime Rodriguez
    Blando, Jorge
    Wistuba, Ignacio I.
    Maitra, Anirban
    Wolff, Robert A.
    Varadhachary, Gauri R.
    Wang, Huamin
    [J]. LABORATORY INVESTIGATION, 2016, 96 : 189A - 189A
  • [32] The Prognostic Significance of Infiltrating Lymphocytes in Patients with Pancreatic Ductal Adenocarcinoma Treated with Neoadjuvant Therapy
    Nejati, Reza
    Halperin, Daniel M.
    Goldstein, Jennifer B.
    Wang, Hua
    Rashid, Asif
    Katz, Matthew H.
    Lee, Jeffrey E.
    Fleming, Jason B.
    Canales, Jaime Rodriguez
    Blando, Jorge
    Wistuba, Ignacio I.
    Maitra, Anirban
    Wolff, Robert A.
    Varadhachary, Gauri R.
    Wang, Huamin
    [J]. MODERN PATHOLOGY, 2016, 29 : 189A - 189A
  • [33] Prognostic and predictive value of tumor-infiltrating lymphocytes in combination with systemic inflammatory markers in colon cancer
    Efil, S. C.
    Guner, G.
    Guven, D. C.
    Celikten, B.
    Celebiyev, E.
    Taban, H.
    Akyol, A.
    Kilickap, S.
    Yalcin, S.
    Dizdar, O.
    [J]. ANNALS OF ONCOLOGY, 2021, 32 : S561 - S561
  • [34] Tumor-infiltrating lymphocytes are important pathologic predictors for neoadjuvant chemotherapy in patients with breast cancer
    Yamaguchi, Rin
    Tanaka, Maki
    Yano, Ayako
    Tse, Gary M.
    Yamaguchi, Miki
    Koura, Keiko
    Kanomata, Naoki
    Kawaguchi, Atsushi
    Akiba, Jun
    Naito, Yoshiki
    Ohshima, Koichi
    Yano, Hirohisa
    [J]. HUMAN PATHOLOGY, 2012, 43 (10) : 1688 - 1694
  • [35] Tumor-infiltrating lymphocytes are an important pathological predictor for neoadjuvant chemotherapy in patients with breast cancer
    Yamaguchi, R.
    Tanaka, M.
    Yano, A.
    Yamaguchi, M.
    Yano, H.
    [J]. BREAST, 2011, 20 : S76 - S76
  • [36] Impact of Tumor-Infiltrating Lymphocytes in Breast Cancer Patients with Neoadjuvant Chemotherapy Depends on Subtypes
    Matsumoto, Akiko
    Jinno, Hiromitsu
    Ishida, Hiroki
    Hiraiwa, Kunihiko
    Nakamura, Tetsuya
    Ueyama, Yoshihito
    Saito, Junichi
    [J]. ANNALS OF ONCOLOGY, 2016, 27
  • [37] Prognostic and Predictive Role of Tumor-Infiltrating Lymphocytes (TILs) in Ovarian Cancer
    Fanale, Daniele
    Dimino, Alessandra
    Pedone, Erika
    Brando, Chiara
    Corsini, Lidia Rita
    Filorizzo, Clarissa
    Fiorino, Alessia
    Lisanti, Maria Chiara
    Magrin, Luigi
    Randazzo, Ugo
    Russo, Tancredi Didier Bazan
    Russo, Antonio
    Bazan, Viviana
    [J]. CANCERS, 2022, 14 (18)
  • [38] Clinicopathological significance and prognostic role of tumor-infiltrating lymphocytes in colorectal cancer
    Ko, Young San
    Pyo, Jung-Soo
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS, 2019, 34 (02): : 132 - 138
  • [39] Prognostic and predictive value of tumor-infiltrating lymphocytes (TILs) in triple-negative breast cancers (TNBC) treated with neoadjuvant chemotherapy (NAC)
    Herrero-Vicent, C.
    Guerrero, A.
    Gavila, J.
    Gozalbo, F.
    Blanch, S.
    Hernandez, A.
    Sandiego, S.
    Calatrava, A.
    Guillem, V.
    Ruiz, A.
    [J]. ANNALS OF ONCOLOGY, 2016, 27
  • [40] Evaluation of the Predictive and Prognostic Values of Stromal Tumor-Infiltrating Lymphocytes in HER2-Positive Breast Cancers treated with neoadjuvant chemotherapy
    Yang, Xia
    Rao, Jia
    Yang, Wentao
    Shui, Ruohong
    [J]. TARGETED ONCOLOGY, 2018, 13 (06) : 757 - 767
12345