Predictive and Prognostic Significance of Tumor-infiltrating Lymphocytes in Patients with Breast Cancer Treated with Neoadjuvant Systemic Therapy

被引：0
|
作者：
Melichar, Bohuslav [1 ]
Studentova, Hana [1 ]
Kalabova, Hana [1 ]
Vitaskova, Denisa [1 ]
Cermakova, Petra [2 ]
Hornychova, Helena [2 ]
Ryska, Ales [2 ]
机构：
[1] Palacky Univ, Med Sch & Teaching Hosp, Dept Oncol, Olomouc 77520, Czech Republic
[2] Charles Univ Prague, Med Sch & Teaching Hosp, Fingerland Inst Pathol, Hradec Kralove, Czech Republic
来源：
ANTICANCER RESEARCH | 2014年 / 34卷 / 03期
关键词：
Breast cancer; targeted therapy; tumor-infiltrating lymphocytes; review; PATHOLOGICAL COMPLETE RESPONSE; REGULATORY T-CELLS; GENE-EXPRESSION PROFILES; SURGICAL ADJUVANT BREAST; HUMAN SOLID TUMORS; PREOPERATIVE CHEMOTHERAPY; ENDOMETRIAL CANCER; URINARY NEOPTERIN; IMMUNE ACTIVATION; RANDOMIZED-TRIAL;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Despite the progress of tailored therapeutic strategies in patients with breast cancer, there is an unmet medical need for additional biomarkers that would guide therapy, including the administration of targeted agents. It has been demonstrated that the presence of tumor-infiltrating lymphocytes (TILs) is associated with prognosis in patients with early breast cancer. Moreover, TIL counts were shown to predict outcome of neoadjuvant chemotherapy. The neoadjuvant setting is increasingly used to assess the efficacy of new systemic therapies, and TILs are promising as a biomarker reflecting the immune response to tumor. Future studies should investigate on the integration of TILs as predictive biomarkers in patients treated with targeted- agents.
引用
收藏
页码：1115 / 1125
页数：11
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