Colubricidin A, a novel macrolide antibiotic from a Streptomyces sp.

被引：10
|
作者：
Kong, FM [1 ]
Liu, DQ [1 ]
Nietsche, J [1 ]
Tischler, M [1 ]
Carter, GT [1 ]
机构：
[1] Wyeth Ayerst Res, Pearl River, NY 10965 USA
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 52期
关键词：
D O I：
10.1016/S0040-4039(99)01968-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new 34-membered macrolide antibiotic, colubricidin A (1), was isolated from the fermentation broth of a new streptomyces species. Its structure was elucidated on the basis of analysis of the spectroscopic data and chemical degradation. It was identified as a glycomacrolide with an unprecedented aromatic chromophore. Colubricidin A showed excellent activity against Gram-positive bacteria. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：9219 / 9223
页数：5
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