A novel isocoumarin with anti-influenza virus activity from Strobilanthes cusia

被引：29
|
作者：
Gu, Wei [1 ,2 ]
Wang, Wei [4 ]
Li, Xiao-nian [3 ]
Zhang, Yu [3 ]
Wang, Li-ping [1 ,2 ]
Yuan, Chun-mao [1 ,2 ]
Huang, Lie-jun [1 ,2 ]
Hao, Xiao-jiang [1 ,2 ,3 ]
机构：
[1] Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Guizhou, Peoples R China
[2] Chinese Acad Sci, Guiyang 550002, Guizhou, Peoples R China
[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
[4] Ocean Univ China, Sch Med & Pharm, Qingdao 266100, Shandong, Peoples R China
来源：
FITOTERAPIA | 2015年 / 107卷
关键词：
Strobilanthes cusia; Novel isocoumarin; Unprecedented skeleton; Anti-influenza virus activity; GLYCOSIDES;
D O I：
10.1016/j.fitote.2015.10.009
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Strobilanthes A (1), a novel isocoumarin with an unusual tetrahydro-4 H-pyran-4-one moiety fused isocoumarin core skeleton, together with a known compound (2) was isolated from Strobilanthes cusia. Its chemical structures were elucidated by 2D NMR spectroscopy, mass spectrometry and single-crystal X-ray diffraction analysis. The biosynthetic pathway of 1 could be supposed to be originally derived from 3-methylisocoumarin, a product of AA-MA pathway. Both of two compounds displayed anti-influenza virus activity in vitro. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：60 / 62
页数：3
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