Growth factors in distraction osteogenesis -: Immuno-histological pattern of TGF-β1 and IGF-I in human callus induced by distraction osteogenesis

被引：55
|
作者：
Eingartner, C [1 ]
Coerper, S [1 ]
Fritz, J [1 ]
Gaissmaier, C [1 ]
Koveker, G [1 ]
Weise, K [1 ]
机构：
[1] Univ Tubingen, BG Trauma Ctr, D-72076 Tubingen, Germany
来源：
INTERNATIONAL ORTHOPAEDICS | 1999年 / 23卷 / 05期
关键词：
D O I：
10.1007/s002640050365
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Although growth factors have been demonstrated during bone healing, their presence has not yet been confirmed in callus distraction. Therefore, in 3 patients we searched for cytokines during callus distraction. Bone biopsies were immuno-histochemically stained for TGF-beta 1, IGF-I, TGF-beta type II receptor, IGF receptor, and proliferating cell nuclear antigen (PCNA). Histologically we found immature woven bone in the middle of the callus zone and increasing calcification and lamellar bone in the re-modelling zone. Osteoblasts and fibroblast-like cells in the middle zone, and osteoblasts in all zones stained for TGF-beta and its receptor. The number of positive staining cells related to proliferous activity as assessed both by PCNA, and by bone density in radiographs. IGF-I could be detected every where. In conclusion, growth factors are present in bone formation and in areas of re-modelling during callotasis. Their relation to proliferous activity and radiographic density supports their involvement in osteogenesis.
引用
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页码：253 / 259
页数：7
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