Effect of Soy Isoflavone Crude Extract Supplementation on High Fat Diet-induced Insulin Resistance in Ovariectomized Rats

被引：4
|
作者：
Zhang Yun Bo [1 ]
Li Li Na [1 ]
Zhao Xin Yu [1 ]
Chen Wen Hua [2 ]
Guo Jing Jing [1 ]
Fu Zheng Hai [1 ]
Yang Yang [1 ]
Na Xiao Lin [1 ]
机构：
[1] Harbin Med Univ, Sch Publ Hlth, Dept Environm Hyg, Harbin 150081, Heilongjiang, Peoples R China
[2] Harbin Med Univ, Sch Publ Hlth, Harbin 150081, Heilongjiang, Peoples R China
来源：
BIOMEDICAL AND ENVIRONMENTAL SCIENCES | 2014年 / 27卷 / 01期
关键词：
POSTMENOPAUSAL WOMEN; GENISTEIN; RISK;
D O I：
10.3967/bes2014.014
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Female Wister rats aged 8 weeks were randomly divided into sham operation group, ovariectomized (OVX) control group, and 2 OVX groups fed with soy isoflavone crude extract supplementation. The rats had free access to high fat diet and water for 9 weeks. No significant difference was found in body weight (BW), total abdominal fat, food intake and food utilization rate between OVX control group and 2 OVX groups. However, the fasting blood glucose and blood lipid levels were significantly higher in 2 OVX groups than in OVX control group (P<0.05). Intraperitoneal glucose tolerance test (IGTT) showed that the area under AUC was smaller in 2 OVX groups than in OVX control group (P<0.05). These findings showed that soy isoflavone crude extract supplementation can improve glucose tolerance and prevent high fat diet-induced insulin resistance in ovariectomized rats.
引用
收藏
页码：49 / 51
页数：3
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