Effect of Soy Isoflavone Crude Extract Supplementation on High Fat Diet-induced Insulin Resistance in Ovariectomized Rats

Female Wister rats aged 8 weeks were randomly divided into sham operation group, ovariectomized (OVX) control group, and 2 OVX groups fed with soy isoflavone crude extract supplementation. The rats had free access to high fat diet and water for 9 weeks. No significant difference was found in body weight (BW), total abdominal fat, food intake and food utilization rate between OVX control group and 2 OVX groups. However, the fasting blood glucose and blood lipid levels were significantly higher in 2 OVX groups than in OVX control group (P<0.05). Intraperitoneal glucose tolerance test (IGTT) showed that the area under AUC was smaller in 2 OVX groups than in OVX control group (P<0.05). These findings showed that soy isoflavone crude extract supplementation can improve glucose tolerance and prevent high fat diet-induced insulin resistance in ovariectomized rats.