The synthesis of a new probe for PET imaging reporter gene HSV1-tk:: 2-amino-6-[18F] fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-[18F]fluoropenciclovir)

被引：6
|
作者：
Cai, Hancheng
Yin, Duanzhi
Zhang, Lan
Wang, Yongxian
机构：
[1] Chinese Acad Sci, Shanghai Inst Appl Phys, Res Ctr Radiopharmaceut, Shanghai 201800, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2006年 / 49卷 / 07期
关键词：
fluorine-18; synthesis; penciclovir; radiofluorination;
D O I：
10.1002/jlcr.1080
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The one step radiosynthesis of 2-amino-6-[F-18]fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-[F-18]fluoropenciclovir) 6 is reported. Radiolabeled product 6-[F-18]fluoropenciclovir 6 was prepared by radiofluorination of compound 4 with [F-18]KF and isolated by a silica Sep-Pak cartridge. The radiochemical yield of compound 6 was 45-55% decay corrected (d.c.) in six runs with radiochemical purity > 98% and the radiosynthesis time was 35-42 min from end of bombardment (EOB). Copyright (c) 2006 John Wiley & Sons, Ltd.
引用
收藏
页码：653 / 661
页数：9
相关论文
共 50 条
  • [41] Evaluation of [18F]fluoroxanomeline {5-{4-[(6-[18F]fluorohexyl)oxy]-1 2,5-thiadiazol-3-yl}-1-methyl-1,2,3,6-tetrahydropyridine}
    Kiesewetter, Dale O.
    Jagoda, Elaine M.
    Shimoji, Kazuaki
    Ma, Ying
    Eckelman, William C.
    NUCLEAR MEDICINE AND BIOLOGY, 2007, 34 (02) : 141 - 152
  • [42] PET imaging of hepatocellular carcinoma with 2-deoxy-2[18F]fluoro-D-glucose, 6-deoxy-6[18F]fluoro-D-glucose, [1-11C]-acetate and [N-methyl-11C]-choline
    Salem, N.
    Kuang, Y.
    Wang, F.
    MacLennan, G. T.
    Lee, Z.
    QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2009, 53 (02): : 144 - 156
  • [43] Synthesis of O-[2-[18F]fluoro-3-(2-nitro-1H-imidazole-1-yl)propyl]tyrosine ([18F]FNT]) as a new class of tracer for imaging hypoxia
    Malik, Noeen
    Lin, Xian
    Loeffler, Dirk
    Shen, Bin
    Solbach, Christoph
    Reischl, Gerald
    Voelter, Wolfgang
    Machulla, Hans-Juergen
    JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 2012, 292 (03) : 1025 - 1033
  • [44] Synthesis of O-[2-[18F]fluoro-3-(2-nitro-1H-imidazole-1-yl)propyl]tyrosine ([18F]FNT]) as a new class of tracer for imaging hypoxia
    Noeen Malik
    Xian Lin
    Dirk Löffler
    Bin Shen
    Christoph Solbach
    Gerald Reischl
    Wolfgang Voelter
    Hans-Jürgen Machulla
    Journal of Radioanalytical and Nuclear Chemistry, 2012, 292 : 1025 - 1033
  • [45] Synthesis and Characterization of 9-(4-[18F]Fluoro-3-(hydroxymethyl)butyl)-2-(phenylthio)-6-oxopurine as a Novel PET Agent for Mutant Herpes Simplex Virus Type 1 Thymidine Kinase Reporter Gene Imaging
    Fuchigami, Takeshi
    Haywood, Tom
    Gowrishankar, Gayatri
    Anders, David
    Namavari, Mohammad
    Wardak, Mirwais
    Gambhir, Sanjiv Sam
    MOLECULAR IMAGING AND BIOLOGY, 2020, 22 (05) : 1151 - 1160
  • [46] Synthesis and Characterization of 9-(4-[18F]Fluoro-3-(hydroxymethyl)butyl)-2-(phenylthio)-6-oxopurine as a Novel PET Agent for Mutant Herpes Simplex Virus Type 1 Thymidine Kinase Reporter Gene Imaging
    Takeshi Fuchigami
    Tom Haywood
    Gayatri Gowrishankar
    David Anders
    Mohammad Namavari
    Mirwais Wardak
    Sanjiv Sam Gambhir
    Molecular Imaging and Biology, 2020, 22 : 1151 - 1160
  • [47] [18F]-9-[(1-fluoro-3-hydroxy-2-pro-poxy)methyl]guanine ([18F]FHPG):: A promising tracer to quantify herpes simplex virus thymidine kinase (HSVTK) enzyme activity with PET.
    de Vries, EFJ
    Doze, P
    van Waarde, A
    Vaalburg, W
    Mulder, NH
    Hospers, GAP
    JOURNAL OF NUCLEAR MEDICINE, 2000, 41 (05) : 263P - 263P
  • [48] Imaging herpes viral thymidine kinase-1 reporter gene expression with a new 18F-labeled probe:: 2′-fluoro-2′-deoxy-5-[18F]fluoroethyl-1-β-D-arabinofuranosyl uracil
    Balatoni, JA
    Doubrovin, M
    Ageyeva, L
    Pillarsetty, N
    Finn, RD
    Gelovani, JG
    Blasberg, RG
    NUCLEAR MEDICINE AND BIOLOGY, 2005, 32 (08) : 811 - 819
  • [49] Synthesis of 2,6-dideoxy-2-fluoro-6-[18F]-fluoro-β-D-glucopyranosyl fluoride (2,6FGF) as a potential imaging probe for glucocerebrosidase
    Wong, AW
    Adam, MJ
    Withers, SG
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2001, 44 (05): : 385 - 394
  • [50] Synthesis and evaluation of 6-[18F]fluoro-3-(pyridin-3-yl)-1H-indole as potential PET tracer for targeting tryptophane 2, 3-dioxygenase (TDO)
    Qiao, Zheng
    Mardon, Karine
    Stimson, Damion H. R.
    Migotto, Mary-anne
    Reutens, David C.
    Bhalla, Rajiv
    NUCLEAR MEDICINE AND BIOLOGY, 2020, 84-85 : 1 - 10
12345