A Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor Alters 5-HT2A Receptor Signaling in a Heteromeric Complex

被引:0
|
作者
Ellaithy, Amr [1 ]
Younkin, Jason [1 ]
Baki, Lia [1 ]
Logothetis, Diomedes [1 ]
机构
[1] Virginia Commonwealth Univ, Richmond, VA USA
关键词
D O I
10.1016/j.bpj.2014.11.2281
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
2096-Pos
引用
收藏
页码:416A / 416A
页数:1
相关论文
共 50 条
  • [41] Reprint of Pharmacological and molecular characterization of the positive allosteric modulators of metabotropic glutamate receptor 2
    Lundstrom, L.
    Bissantz, C.
    Beck, J.
    Dellenbach, M.
    Woltering, T. J.
    Wichmann, J.
    Gatti, S.
    NEUROPHARMACOLOGY, 2017, 115 : 115 - 127
  • [42] Cortical 5-HT2A receptor density predicts 5-HT2A receptor mediated behavior in the rabbit
    Dave, KD
    Harvey, JA
    Aloyo, VJ
    FASEB JOURNAL, 2006, 20 (04): : A686 - A686
  • [43] Process research and development of BMS-955829, a positive allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5)
    Bobes, Francisco Gonzalez
    Strotman, Neil
    Ronald, Hanson
    Goswami, Animesh
    Guo, Zhiwei
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 250
  • [44] Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2
    Liauw, Brandon Wey-Hung
    Foroutan, Arash
    Schamber, Michael R.
    Lu, Weifeng
    Afsari, Hamid Samareh
    Vafabakhsh, Reza
    ELIFE, 2022, 11
  • [45] POSITIVE SEROTONIN 5-HT2A/2C RECEPTOR ALLOSTERIC MODULATORS DERIVED FROM OLEAMIDE COMPOUNDS
    Zamora, Joshua
    Anastasio, Noelle
    Zhou, Jia
    Cunningham, Kathryn
    DRUG AND ALCOHOL DEPENDENCE, 2024, 260
  • [46] Enantioselective Synthesis of a Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 5 (mGluR5) Receptor via Dynamic Kinetic Resolution of -Amino Ketones
    Gonzalez-Bobes, Francisco
    Hanson, Ronald
    Strotman, Neil
    Guo, Zhiwei
    Goswami, Animesh
    ADVANCED SYNTHESIS & CATALYSIS, 2016, 358 (13) : 2077 - 2082
  • [47] Molecular Switches of Allosteric Modulation of the Metabotropic Glutamate 2 Receptor
    Perez-Benito, Laura
    Doornbos, Maarten L. J.
    Cordomi, Arnau
    Peeters, Luc
    lavreysen, Hilde
    Pardo, Leonardo
    Tresadern, Gary
    STRUCTURE, 2017, 25 (07) : 1153 - +
  • [48] Discovery of Novel Oleamide Analogues as Brain-Penetrant Positive Allosteric Serotonin 5-HT2C Receptor and Dual 5-HT2C/5-HT2A Receptor Modulators
    Chen, Jianping
    Garcia, Erik J.
    Merritt, Christina R.
    Zamora, Joshua C.
    Bolinger, Andrew A.
    Pazdrak, Konrad
    Stafford, Susan J.
    Mifflin, Randy C.
    Wold, Eric A.
    Wild, Christopher T.
    Chen, Haiying
    Anastasio, Noelle C.
    Cunningham, Kathryn A.
    Zhou, Jia
    JOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (14) : 9992 - 10009
  • [49] Exploration of the 5-HT2A: 5-HT2C receptor protein complex in vitro
    Felsing, Daniel E.
    Anastasio, Noelle C.
    Gilbertson, Scott R.
    Moeller, Gerard F.
    Cunningham, Kathryn A.
    Allen, John A.
    FASEB JOURNAL, 2017, 31
  • [50] Radiosynthesis and evaluation of a negative allosteric modulator for the PET imaging of metabotropic glutamate receptor 2 in rat brain
    Kumata, Katsushi
    Zhang, Yiding
    Hatori, Akiko
    Yamasaki, Tomoteru
    Kurihara, Yusuke
    Nengaki, Nobuki
    Zhang, Ming-Rong
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2019, 62 : S395 - S396