Molecular mechanisms of lncRNAs in regulating cancer cell radiosensitivity

被引：39
|
作者：
Zhu, Jiamin [1 ,2 ]
Chen, Shusen [2 ]
Yang, Baixia [2 ]
Mao, Weidong [1 ]
Yang, Xi [3 ]
Cai, Jing [2 ]
机构：
[1] Southeast Univ, Coll Med, Affiliated Jiangyin Hosp, Dept Oncol, 163 Shoushan Rd, Jiangyin 214400, Peoples R China
[2] Nantong Univ, Affiliated Tumor Hosp, Nantong Tumor Hosp, Dept Radiat Oncol, Nantong 226321, Peoples R China
[3] Fudan Univ, Shanghai Med Coll, Dept Oncol, Dept Radiat Oncol,Shanghai Canc Ctr, Shanghai 200032, Peoples R China
来源：
BIOSCIENCE REPORTS | 2019年 / 39卷
基金：
中国国家自然科学基金;
关键词：
LONG NONCODING RNA; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN COLORECTAL-CANCER; ENHANCES RADIOSENSITIVITY; DOWN-REGULATION; LUNG-CANCER; NASOPHARYNGEAL CARCINOMA; RADIATION-RESISTANCE; TUMOR-CELLS; STEM-CELLS;
D O I：
10.1042/BSR20190590
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Radiotherapy is one of the main modalities of cancer treatment. However, tumor recurrence following radiotherapy occurs in many cancer patients. A key to solving this problem is the optimization of radiosensitivity. In recent years, long non-coding RNAs (lncRNAs), which affect the occurrence and development of tumors through a variety of mechanisms, have become a popular research topic. LncRNAs have been found to influence radiosensitivity by regulating various mechanisms, including DNA damage repair, cell cycle arrest, apoptosis, cancer stem cells regulation, epithelial-mesenchymal transition, and autophagy. LncRNAs are expected to become a potential therapeutic target for radiotherapy in the future. This article reviews recent advances in the role and mechanism of lncRNAs in tumor radiosensitivity.
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页数：9
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