Asymmetric [4+2]-Cycloaddition of Copper-Allenylidenes with Hexahydro-1,3,5-triazines: Access to Chiral Tetrahydroquinazolines

被引：79

作者：

Ji, Danqing ^{[1
]}

Wang, Cheng ^{[1
]}

Sun, Jiangtao ^{[1
]}

机构：

[1] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, Changzhou 213164, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 12期

基金：

中国国家自然科学基金;

关键词：

DONOR-ACCEPTOR CYCLOPROPANES; PROPARGYLIC ESTERS; ENANTIOSELECTIVE PROPARGYLATION; 3+2 CYCLOADDITION; BETA-KETOESTERS; 1,3,5-TRIAZINANES; DEAROMATIZATION; ANNULATION; COMPLEXES; IMINES;

D O I：

10.1021/acs.orglett.8b01584

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed asymmetric formal [4 + 2]-cycloaddition of copper-allenylidenes and hexahydro-1,3,5-triazines has been developed, providing chiral tetrahydroquinazolines in moderate to good yields and with high enantioselectivities for most cases (up to 88% yield and 98% ee).

引用

页码：3710 / 3713

页数：4

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